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anti-CSE1L antibody :: Mouse anti-Human CSE1L Monoclonal Antibody

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Catalog # MBS120449
Unit / Price
  0.1 mg  /  $345 +1 FREE 8GB USB
Product Name

CSE1L, Monoclonal Antibody

Also Known As

Mouse monoclonal antibody Anti-Human CSE1L

Product Synonym Names
Homo sapiens CSE1 chromosome segregation 1-like (yeast) (CSE1L), mRNA.; CAS; CSE1; XPO2; MGC117283; MGC130036; MGC130037
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
3627
Immunogen Sequence
DEEFQRYLPR FVTAIWNLLV TTGQEVKYDL LVSNAIQFLA SVCERPHYKN LFEDQNTLTS ICEKVIVPNM EFRAADEEAF EDNSEEYIRR DLEGSDIDTR RRAA
OMIM
601342
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
2218C5a
Host
Mouse
Species Reactivity
Human
Concentration
100 ug/ml (1.0 ml) (lot specific)
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Other Notes
Small volumes of anti-CSE1L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CSE1L antibody
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importinalpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.[NCBI Entrez Gene Summary]
Applications Tested/Suitable for anti-CSE1L antibody
Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB)

Quality Control of anti-CSE1L antibody
Western blot analysis of immunized recombinant protein, using anti-CSE1L monoclonal antibody.
anti-CSE1L antibody Quality Control image
Quality Control #2 of anti-CSE1L antibody
Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-CSE1L antibody Quality Control #2 image
Western Blot (WB) of anti-CSE1L antibody
Detection of CSE1L by Western blot.

Samples: Whole cell lysate from human HEK293 (H, 25 ug), mouse NIH3T3 (M, 25 ug) and rat F2408 (R, 25 ug) cells. [Lot No. 2218C5a-1]

Predicted molecular weight: 110 kDa
anti-CSE1L antibody Western Blot (WB) (WB) image
Immunocytochemistry (ICC) of anti-CSE1L antibody
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-CSE1L mAb. [Lot No.2218C5a-1]
anti-CSE1L antibody Immunocytochemistry (ICC) (ICC) image
NCBI/Uniprot data below describe general gene information for CSE1L. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
103,879 Da
NCBI Official Full Name
Homo sapiens CSE1 chromosome segregation 1-like (yeast) (CSE1L), transcript variant 1, mRNA
NCBI Official Synonym Full Names
CSE1 chromosome segregation 1-like (yeast)
NCBI Official Symbol
CSE1L  [Similar Products]
NCBI Official Synonym Symbols
CAS; CSE1; XPO2
  [Similar Products]
NCBI Protein Information
exportin-2; cellular apoptosis susceptibility protein; chromosome segregation 1-like protein; exp2; importin-alpha re-exporter
UniProt Protein Name
Exportin-2
UniProt Synonym Protein Names
Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Importin-alpha re-exporter
UniProt Gene Name
CSE1L  [Similar Products]
UniProt Entry Name
XPO2_HUMAN
NCBI Summary for CSE1L
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for CSE1L
Exportin-2: Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the XPO2/CSE1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear import; Nuclear export; Karyopherin

Chromosomal Location of Human Ortholog: 20q13

Cellular Component: nucleoplasm; membrane; cytoplasm; nucleus

Molecular Function: importin-alpha export receptor activity; protein binding; Ran GTPase binding

Biological Process: cell proliferation; apoptosis; protein export from nucleus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-CSE1L antibody
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