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anti-CAMK2A antibody :: Mouse anti-Human Cytokeratin 8,18,19 Monoclonal Antibody

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Catalog # MBS609881
Unit / Price
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  0.1 mg  /  $730 +1 FREE 8GB USB
anti-CAMK2A antibody
Product Name

Cytokeratin 8,18,19 (CAMK2A), Monoclonal Antibody

Full Product Name

Cytokeratin 8,18,19 (Cytokeratin 8, Cytokeratin-8, CK 8, CK8, CK-8, Cyk8, Cytokeratin 18, Cytokeratin-18, CK 18, CK18, CK-18, CYK18, Cytokeratin 19, Cytokeratin-19, CK 19, CK19, CK-19)

Product Synonym Names
Anti -Cytokeratin 8,18,19 (Cytokeratin 8, Cytokeratin-8, CK 8, CK8, CK-8, Cyk8, Cytokeratin 18, Cytokeratin-18, CK 18, CK18, CK-18, CYK18, Cytokeratin 19, Cytokeratin-19, CK 19, CK19, CK-19)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 5; NC_000005.9 (149599054..149669403, complement). Location: 5q32
OMIM
114078
3D Structure
ModBase 3D Structure for Q9UQM7
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2A4
Host
Mouse
Species Reactivity
Human
Specificity
Recognizes human cytokeratin 8, 18 and 19. Typical for simple epithelial cells.
Purity/Purification
Ascites
Serum
Form/Format
Supplied as a liquid in PBS, 1% BSA, 0.1% sodium azide.
Immunogen
Cytokeratins isolated from cultured pig kidney epithelial cells
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Other Notes
Small volumes of anti-CAMK2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CAMK2A antibody
The cytoplasmic cytoskeleton determines cell organization, shape and adhesion among other functions. Furthermore, the cell type-specific expression of intermediate filaments allows determination of the origin of many, otherwise unspecific tumors.
Applications Tested/Suitable for anti-CAMK2A antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CAMK2A antibody
Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1:1000
Immunohistochemistry: Frozen
NCBI/Uniprot data below describe general gene information for CAMK2A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,088 Da[Similar Products]
NCBI Official Full Name
calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2
NCBI Official Synonym Full Names
calcium/calmodulin-dependent protein kinase II alpha
NCBI Official Symbol
CAMK2A  [Similar Products]
NCBI Official Synonym Symbols
CAMKA
  [Similar Products]
NCBI Protein Information
calcium/calmodulin-dependent protein kinase type II subunit alpha; CaMKIINalpha; CaMK-II alpha subunit; caMK-II subunit alpha; CaM-kinase II alpha chain; CaM kinase II alpha subunit; caM kinase II subunit alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
UniProt Protein Name
Calcium/calmodulin-dependent protein kinase type II subunit alpha
UniProt Gene Name
CAMK2A  [Similar Products]
UniProt Synonym Gene Names
CAMKA; KIAA0968; CaM kinase II subunit alpha  [Similar Products]
UniProt Entry Name
KCC2A_HUMAN
NCBI Summary for CAMK2A
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]
UniProt Comments for CAMK2A
CAMK2A: a protein kinase of the CAMK2 family. A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses that may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. The holoenzyme is composed of four different chains: alpha, beta, gamma, and delta. The different chains assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. May interact with BAALC, MPDZ, SYN1 and synGAP. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.11.17; Protein kinase, CAMK; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMK2 family

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: presynaptic membrane; nucleoplasm; mitochondrion; plasma membrane; cytosol; cell junction; nucleus

Molecular Function: calmodulin binding; protein serine/threonine kinase activity; protein binding; glutamate receptor binding; protein homodimerization activity; calmodulin-dependent protein kinase activity; kinase activity; ATP binding

Biological Process: synaptic transmission; peptidyl-serine phosphorylation; cytokine and chemokine mediated signaling pathway; protein amino acid autophosphorylation; calcium ion transport; regulation of neurotransmitter secretion; positive regulation of calcium ion transport; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; regulation of neuronal synaptic plasticity; G1/S transition of mitotic cell cycle
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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