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anti-ARHGDIB antibody :: Mouse anti-Human D4-GDI Monoclonal Antibody

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Catalog # MBS601449
Unit / Price
  0.1 mg  /  $730 +1 FREE 8GB USB
anti-ARHGDIB antibody
Product Name

D4-GDI (ARHGDIB), Monoclonal Antibody

Also Known As

D4-GDI (GDP Dissociation Inhibitor, Rho GDP-dissociation Inhibitor 2, Rho GDI 2, Ly-GDI, Rho-GDI beta, ARHGDIB, GDIA2, GDID4, RAP1GN1) (Biotin)

Product Synonym Names
Anti -D4-GDI (GDP Dissociation Inhibitor, Rho GDP-dissociation Inhibitor 2, Rho GDI 2, Ly-GDI, Rho-GDI beta, ARHGDIB, GDIA2, GDID4, RAP1GN1) (Biotin)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 5; NC_007303.4 (101692667..101711560)
3D Structure
ModBase 3D Structure for Q9TU03
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
8J1255
Host
Mouse
Species Reactivity
Human
Specificity
Recognizes human D4-GDI at ~28kD.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide. Labeled with Biotin.
Immunogen
Synthetic peptide corresponding to human D4-GDI.
Positive Control
Whole cell lysate from Daudi or Jurkat cells
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Other Notes
Small volumes of anti-ARHGDIB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ARHGDIB antibody
D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras-related Rho family of GTPases. Since the Rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28kD mature form of D4-GDI to give a 23kD and 5kD size fragment. The 23kD fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-terminal kinase, a regulator of apoptosis, may be one of the mechanisms.
Applications Tested/Suitable for anti-ARHGDIB antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ARHGDIB antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1-2ug/ml
NCBI/Uniprot data below describe general gene information for ARHGDIB. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,794 Da[Similar Products]
NCBI Official Full Name
D4-GDP-dissociation inhibitor
NCBI Official Symbol
ARHGDIB  [Similar Products]
NCBI Protein Information
rho GDP-dissociation inhibitor 2; D4-GDI; ly-GDI; rho GDI 2; rho-GDI beta; D4-GDP-dissociation inhibitor
UniProt Protein Name
Rho GDP-dissociation inhibitor 2
UniProt Synonym Protein Names
D4-GDP-dissociation inhibitor; D4-GDI; Ly-GDI; Rho-GDI beta
UniProt Gene Name
ARHGDIB  [Similar Products]
UniProt Synonym Gene Names
GDID4  [Similar Products]
UniProt Entry Name
GDIR2_BOVIN
UniProt Comments for ARHGDIB
Function: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

Subcellular location: Cytoplasm.

Sequence similarities: Belongs to the Rho GDI family.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-ARHGDIB antibody
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