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anti-DSG1 antibody :: Mouse Desmoglein 1 Monoclonal Antibody

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Catalog # MBS530355
Unit / Price
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  5 mL  /  $395 +1 FREE 8GB USB
anti-DSG1 antibody
Product Name

Desmoglein 1 (DSG1), Monoclonal Antibody

Popular Item
Full Product Name

Desmoglein 1 antibody

Product Synonym Names
Monoclonal Desmoglein 1; Anti-Desmoglein 1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
125670
3D Structure
ModBase 3D Structure for Q02413
Clonality
Monoclonal
Isotype
IgG1
Clone Number
Dsg1-P23
Host
Mouse
Species Reactivity
Human desmoglein 1
Purity/Purification
Culture supernatant
Form/Format
Hybridoma culture supernatant with 0.09% NaN3
Concentration
5.0ml per vial (lot specific)
Biological Significance
The desmogleins are a family of cadherins consisting of proteins DSG1, DSG2, DSG3, and DSG4. They play a role in the formation of desmosomes that join cells to one another. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Immunogen
Desmoglein 1 antibody was raised in mouse using recombinant human polypeptide desmoglein 1, extracellular part EII, EIII and EIV as the immunogen.
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of anti-DSG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DSG1 antibody
Mouse monoclonal Desmoglein 1 antibody
Product Categories/Family for anti-DSG1 antibody
Applications Tested/Suitable for anti-DSG1 antibody
Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB)
NCBI/Uniprot data below describe general gene information for DSG1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,619 Da[Similar Products]
NCBI Official Full Name
desmoglein-1 preproprotein
NCBI Official Synonym Full Names
desmoglein 1
NCBI Official Symbol
NCBI Official Synonym Symbols
DG1; DSG; CDHF4; EPKHE; PPKS1; SPPK1; EPKHIA
  [Similar Products]
NCBI Protein Information
desmoglein-1
UniProt Protein Name
Desmoglein-1
UniProt Synonym Protein Names
Cadherin family member 4; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CDHF4; DG1; DGI  [Similar Products]
UniProt Entry Name
DSG1_HUMAN
NCBI Summary for DSG1
This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]
UniProt Comments for DSG1
DSG1: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in DSG1 are the cause of palmoplantar keratoderma striate type 1 (SPPK1); also known as keratosis palmoplantaris striata I. SPPK1 is a dermatoligical disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q12.1

Cellular Component: desmosome; internal side of plasma membrane; apical plasma membrane; plasma membrane; integral to membrane; intercellular junction; cytosol; lateral plasma membrane

Molecular Function: toxin binding; gamma-catenin binding; calcium ion binding

Biological Process: intercellular junction assembly; cell-cell adhesion; maternal process involved in pregnancy; protein stabilization; apoptosis; calcium-dependent cell-cell adhesion; response to progesterone stimulus; homophilic cell adhesion; cell structure disassembly during apoptosis

Disease: Palmoplantar Keratoderma I, Striate, Focal, Or Diffuse; Erythroderma, Congenital, With Palmoplantar Keratoderma, Hypotrichosis, And Hyper-ige
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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