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anti-DHX9 antibody :: Mouse anti-Human DHX9 Monoclonal Antibody

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Catalog # MBS120267
Unit / Price
  0.1 mg  /  $345 +1 FREE 8GB USB
Product Name

DHX9, Monoclonal Antibody

Popular Item
Also Known As

Mouse monoclonal antibody Anti-Human DHX9

Product Synonym Names
Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 9 (DHX9), transcript variant 1; LKP; RHA; DDX9; NDHII; NDH II
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
4543
OMIM
603115
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
2274D5a
Host
Mouse
Species Reactivity
Human
Concentration
100 ug/ml (1.0 ml) (lot specific)
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Other Notes
Small volumes of anti-DHX9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DHX9 antibody
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein with RNA helicase activity. It may participate in melting of DNA:RNA hybrids, such as those that occur during transcription, and may play a role in X-linked gene expression. It contains 2 copies of a double-stranded RNA-binding domain, a DEXH core domain and an RGG box. The RNA-binding domains and RGG box influence and regulate RNA helicase activity. [NCBI Entrez Gene Summary]
Applications Tested/Suitable for anti-DHX9 antibody
Dot Blot (DB)

Quality Control of anti-DHX9 antibody
Western blot analysis of immunized recombinant protein, using anti-DHX9 monoclonal antibody.
anti-DHX9 antibody Quality Control image
Quality Control #2 of anti-DHX9 antibody
Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-DHX9 antibody Quality Control #2 image
NCBI/Uniprot data below describe general gene information for DHX9. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,336 Da
NCBI Official Full Name
Homo sapiens DEAH (Asp-Glu-Ala-His) box helicase 9 (DHX9), transcript variant 1, mRNA
NCBI Official Synonym Full Names
DEAH (Asp-Glu-Ala-His) box helicase 9
NCBI Official Symbol
NCBI Official Synonym Symbols
LKP; RHA; DDX9; NDH2; NDHII
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NCBI Protein Information
ATP-dependent RNA helicase A; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9; DEAH (Asp-Glu-Ala-His) box polypeptide 9; DEAH box protein 9; leukophysin; nuclear DNA helicase II
UniProt Protein Name
ATP-dependent RNA helicase A
UniProt Synonym Protein Names
DEAH box protein 9; Leukophysin; LKP; Nuclear DNA helicase II; NDH II
UniProt Gene Name
UniProt Entry Name
DHX9_HUMAN
NCBI Summary for DHX9
This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010]
UniProt Comments for DHX9
DDX9: a helicase that unwinds double-stranded DNA and RNA in a 3' to 5' direction. Interacts with the RNA-induced silencing complex (RISC) in human cells and functions in RISC loading. Generates multiple secondary structures that influence RNA-binding proteins. Has a dsRNA binding motif at the N-terminus, RGG-box at the carboxyl terminus, and a bidirectional nuclear transport domain of 110 amino acids at the carboxyl terminus. May play a role in X-linked gene expression.

Protein type: Nucleolus; RNA processing; RNA splicing; Nuclear receptor co-regulator; EC 3.6.4.13; RNA-binding; Helicase; Spliceosome

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: nucleoplasm; centrosome; membrane; cytoplasm; nucleolus; cytosol; nucleus; ribonucleoprotein complex

Molecular Function: ATP-dependent DNA helicase activity; protein binding; DNA binding; ATP binding; RNA helicase activity; ATP-dependent RNA helicase activity

Biological Process: circadian rhythm; osteoblast differentiation; nuclear mRNA splicing, via spliceosome; RNA processing; RNA splicing; positive regulation of interferon type I production; innate immune response; gene expression; DNA duplex unwinding
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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