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anti-DBI antibody :: Mouse anti-Human Diazepam Binding Inhibitor Monoclonal Antibody

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Catalog # MBS609259
Unit / Price
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  0.1 mg  /  $545 +1 FREE 8GB USB
anti-DBI antibody
Product Name

Diazepam Binding Inhibitor (DBI), Monoclonal Antibody

Full Product Name

Diazepam Binding Inhibitor (DBI, Acyl-CoA-binding Protein, ACBP, Endozepine, EP)

Product Synonym Names
Anti -Diazepam Binding Inhibitor (DBI, Acyl-CoA-binding Protein, ACBP, Endozepine, EP)
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 2; NC_000002.11 (120124504..120130122). Location: 2q12-q21
OMIM
125950
3D Structure
ModBase 3D Structure for P07108
Clonality
Monoclonal
Isotype
IgG1, k
Clone Number
10K185
Host
Mouse
Species Reactivity
Human
Specificity
Recognizes human Diazepam Binding Inhibitor.
Purity/Purification
Ascites
Ascites
Form/Format
Supplied as a liquid in PBS, 50% glycerol.
Immunogen
Recombinant human GST fusion protein purified from E.coli.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-DBI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DBI antibody
Diazepam Binding Inhibitor (DBI) is a highly conserved 10kD polypeptide which is expressed in various species range from yeast to mammals. As an inverse agonist for benzodiazepine receptors, DBI downregulates inhibitory effects of GABA. It also has potential to induce anxiety. Found in central andperipheral tissues, DBI also participates in metabolism of steroids, which has been known to partially modify GABAA receptor function in the CNS. In peripheral tissues, DBI plays regulatory roles in steroidogenesis. DBI levels have been reported to be decreased in the cerebrospinal fluid obtained from patients with Alzheimer disease.
Product Categories/Family for anti-DBI antibody
Applications Tested/Suitable for anti-DBI antibody
ELISA (EL/EIA), Immunoprecipitation (IP)
Application Notes for anti-DBI antibody
Suitable for use in ELISA and Immunoprecipitation.
Dilution: Immunoprecipitation: 1-2ul/400ul lysates
NCBI/Uniprot data below describe general gene information for DBI. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,044 Da[Similar Products]
NCBI Official Full Name
diazepam binding inhibitor
NCBI Official Synonym Full Names
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
NCBI Official Symbol
NCBI Official Synonym Symbols
EP; ACBP; ACBD1; CCK-RP; MGC70414
  [Similar Products]
NCBI Protein Information
acyl-CoA-binding protein; endozepine; OTTHUMP00000203626; OTTHUMP00000203627; OTTHUMP00000203628; OTTHUMP00000203629; GABA receptor modulator; diazepam-binding inhibitor; acyl coenzyme A binding protein; acyl-Coenzyme A binding domain containing 1; cholecystokinin-releasing peptide, trypsin-sensitive; diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)
UniProt Protein Name
Acyl-CoA-binding protein
UniProt Synonym Protein Names
Diazepam-binding inhibitor; DBI; Endozepine
Protein Family
UniProt Gene Name
UniProt Entry Name
ACBP_HUMAN
NCBI Summary for DBI
This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
UniProt Comments for DBI
DBI: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. Belongs to the ACBP family. 6 isoforms of the human protein are produced by alternative promoter.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 2q12-q21

Cellular Component: Golgi apparatus; mitochondrion; endoplasmic reticulum

Molecular Function: protein dimerization activity; benzodiazepine receptor binding; lipid binding

Biological Process: behavioral fear response; protein palmitoylation; triacylglycerol metabolic process; learning and/or memory; hair follicle development; transport; lateral ventricle development
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-DBI antibody
 Reference Product  PubMed Publications
 TSPO antibody  >4 publications with DBI and TSPO
Pathways associated with anti-DBI antibody
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