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anti-DR3 antibody :: Mouse anti-Human DR3 Monoclonal Antibody

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Catalog # MBS834956
Unit / Price
  0.1 mg  /  $400 +1 FREE 8GB USB
anti-DR3 antibody
Product Name

DR3, Monoclonal Antibody

Popular Item
Full Product Name

DR3 antibody

Product Synonym Names
Monoclonal DR3; Anti-DR3; Apo-3; Tyrosine-rich acidic matrix protein; TRAIL Receptor family; DR 3; DR-3; DR3; TRAMP
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
603366
3D Structure
ModBase 3D Structure for Q93038
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
JD3
Host
Mouse
Species Reactivity
Human
Purity/Purification
DR3 antibody was purified by affinity chromatography.
Form/Format
Affinity purified supplied as liquid in PBS, pH 7.2, with 0.09% NaN3
Concentration
0.5 mg/ml (lot specific)
Biological Significance
The JD3 monoclonal antibody reacts with human DR3, also known as Apo-3, WSL-1, TRAMP, LARD, DDR3, and TR3. DR3, a novel death receptor is expressed at low level by monocytes and granulocytes. Interaction of DR3 with its ligand activates NF-kappaB pathway and induces apoptosis. Initially, DR3 was thought to be a receptor for TWEAK, but further studies have shown that TWEAK could induce apoptosis via receptors distinct from DR3. JD3 has been reported for use in flow cytometric analysis.
Preparation and Storage
Store at 4°C. Do not freeze. Protect from light.
Other Notes
Small volumes of anti-DR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DR3 antibody
Mouse monoclonal DR3 antibody
Product Categories/Family for anti-DR3 antibody
Applications Tested/Suitable for anti-DR3 antibody
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC)
Application Notes for anti-DR3 antibody
A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal /formance in the assay of interest
NCBI/Uniprot data below describe general gene information for DR3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,111 Da
NCBI Official Full Name
DR3
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 25
NCBI Official Symbol
TNFRSF25  [Similar Products]
NCBI Official Synonym Symbols
DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; WSL-LR; TNFRSF12
  [Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 25
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 25
UniProt Synonym Protein Names
Apo-3; Apoptosis-inducing receptor AIR; Apoptosis-mediating receptor DR3; Apoptosis-mediating receptor TRAMP; Death receptor 3; Lymphocyte-associated receptor of death; LARD; Protein WSL; Protein WSL-1
UniProt Gene Name
TNFRSF25  [Similar Products]
UniProt Synonym Gene Names
APO3; DDR3; DR3; TNFRSF12; WSL; WSL1; LARD  [Similar Products]
UniProt Entry Name
TNR25_HUMAN
NCBI Summary for DR3
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]
UniProt Comments for DR3
TNFRSF25: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4. Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate. 12 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.2

Cellular Component: integral to plasma membrane; extracellular region; plasma membrane; cytosol

Molecular Function: tumor necrosis factor receptor activity; receptor activity

Biological Process: regulation of apoptosis; cell surface receptor linked signal transduction; tumor necrosis factor-mediated signaling pathway; apoptosis; signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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