• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-TXNDC5 antibody :: Mouse anti-Human EndoPDI Monoclonal Antibody

Scan QR to view Datasheet
Catalog # MBS804355
Unit / Price
Scan QR to view Datasheet
  0.1 mg  /  $435 +1 FREE 8GB USB
anti-TXNDC5 antibody
Product Name

EndoPDI (TXNDC5), Monoclonal Antibody

Full Product Name

EndoPDI Antibody: Biotin

Product Synonym Names
TXNDC5; Thioredoxin domain containing 5; ERP46; UNQ364; MGC3178; FLJ21353; FLJ90810; thioredoxin related protein; endothelial protein disulphide isomeras
Matching Pairs
Unconjugated Antibody: EndoPDI Clone #2E7/7 (MBS800813)
Biotin Conjugated Antibody: EndoPDI Clone #2E7/7 (MBS804355)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8NBS9
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
2E7/7
Host
Mouse
Species Reactivity
Human
Form/Format
Protein G Purified
Concentration
1mg/mL (lot specific)
Conjugate
Biotin
Storage Buffer
PBS pH7.4, 50% glyercol, 0.09% sodium azide
Preparation and Storage
-20 degree C
Other Notes
Small volumes of anti-TXNDC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TXNDC5 antibody
Background Info: Detects a protein with a mass of ~48kDa corresponding to EndoPDI

Scientific Background: Endothelial protein disulfide isomerase (EndoPDI) is a thioredoxin member of the protein disulfide isomerase family of chaperones. This enzyme has been localized to the endoplasmic reticulum in primary endothelial cells, but colocalizes with nucleoli in the nuclei of breast, colon, and renal cancer cells. EndoPDI mRNA and protein expression is induced by hypoxia and exhibits a protective effect on endothelial cells during hypoxia (1).
Product Categories/Family for anti-TXNDC5 antibody
Applications Tested/Suitable for anti-TXNDC5 antibody
ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-TXNDC5 antibody
1:200 (WB)
NCBI/Uniprot data below describe general gene information for TXNDC5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,178 Da[Similar Products]
NCBI Official Full Name
thioredoxin domain-containing protein 5 isoform 3
NCBI Official Synonym Full Names
thioredoxin domain containing 5 (endoplasmic reticulum)
NCBI Official Symbol
TXNDC5  [Similar Products]
NCBI Official Synonym Symbols
ERP46; HCC-2; STRF8; PDIA15; UNQ364; ENDOPDI
  [Similar Products]
NCBI Protein Information
thioredoxin domain-containing protein 5; ER protein 46; thioredoxin related protein; thioredoxin-like protein p46; endoplasmic reticulum protein ERp46; endothelial protein disulphide isomerase; endoplasmic reticulum resident protein 46; protein disulfide isomerase family A, member 15
UniProt Protein Name
Thioredoxin domain-containing protein 5
UniProt Synonym Protein Names
Endoplasmic reticulum resident protein 46; ER protein 46; ERp46; Thioredoxin-like protein p46
UniProt Gene Name
TXNDC5  [Similar Products]
UniProt Synonym Gene Names
TLP46; UNQ364/PRO700; ER protein 46; ERp46  [Similar Products]
UniProt Entry Name
TXND5_HUMAN
NCBI Summary for TXNDC5
This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. [provided by RefSeq, Dec 2010]
UniProt Comments for TXNDC5
TXNDC5: Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast. Belongs to the protein disulfide isomerase family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p24.3

Cellular Component: lysosomal lumen; endoplasmic reticulum lumen; endoplasmic reticulum

Molecular Function: protein binding; protein disulfide isomerase activity

Biological Process: protein folding; cell redox homeostasis; post-Golgi vesicle-mediated transport; apoptotic cell clearance; negative regulation of apoptosis
Product References and Citations for anti-TXNDC5 antibody
1. Sullivan D.C., et al. (2003) J Biol Chem. 278 (47) 47079-47088.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000