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anti-TXNDC5 antibody :: Mouse anti-Human EndoPDI Monoclonal Antibody

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Catalog # MBS804355
Unit / Price
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  0.1 mg  /  $435 +1 FREE 8GB USB
anti-TXNDC5 antibody
Product Name

EndoPDI (TXNDC5), Monoclonal Antibody

Full Product Name

EndoPDI Antibody: Biotin

Product Synonym Names
TXNDC5; Thioredoxin domain containing 5; ERP46; UNQ364; MGC3178; FLJ21353; FLJ90810; thioredoxin related protein; endothelial protein disulphide isomeras
Matching Pairs
Unconjugated Antibody: EndoPDI Clone #2E7/7 (MBS800813)
Biotin Conjugated Antibody: EndoPDI Clone #2E7/7 (MBS804355)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8NBS9
Clone Number
Species Reactivity
Protein G Purified
1mg/mL (lot specific)
Storage Buffer
PBS pH7.4, 50% glyercol, 0.09% sodium azide
Preparation and Storage
-20 degree C
Other Notes
Small volumes of anti-TXNDC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TXNDC5 antibody
Background Info: Detects a protein with a mass of ~48kDa corresponding to EndoPDI

Scientific Background: Endothelial protein disulfide isomerase (EndoPDI) is a thioredoxin member of the protein disulfide isomerase family of chaperones. This enzyme has been localized to the endoplasmic reticulum in primary endothelial cells, but colocalizes with nucleoli in the nuclei of breast, colon, and renal cancer cells. EndoPDI mRNA and protein expression is induced by hypoxia and exhibits a protective effect on endothelial cells during hypoxia (1).
Product Categories/Family for anti-TXNDC5 antibody
Applications Tested/Suitable for anti-TXNDC5 antibody
ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-TXNDC5 antibody
1:200 (WB)
NCBI/Uniprot data below describe general gene information for TXNDC5. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,178 Da[Similar Products]
NCBI Official Full Name
thioredoxin domain-containing protein 5 isoform 3
NCBI Official Synonym Full Names
thioredoxin domain containing 5 (endoplasmic reticulum)
NCBI Official Symbol
TXNDC5  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
thioredoxin domain-containing protein 5; ER protein 46; thioredoxin related protein; thioredoxin-like protein p46; endoplasmic reticulum protein ERp46; endothelial protein disulphide isomerase; endoplasmic reticulum resident protein 46; protein disulfide isomerase family A, member 15
UniProt Protein Name
Thioredoxin domain-containing protein 5
UniProt Synonym Protein Names
Endoplasmic reticulum resident protein 46; ER protein 46; ERp46; Thioredoxin-like protein p46
UniProt Gene Name
TXNDC5  [Similar Products]
UniProt Synonym Gene Names
TLP46; UNQ364/PRO700; ER protein 46; ERp46  [Similar Products]
UniProt Entry Name
NCBI Summary for TXNDC5
This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. [provided by RefSeq, Dec 2010]
UniProt Comments for TXNDC5
TXNDC5: Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast. Belongs to the protein disulfide isomerase family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p24.3

Cellular Component: lysosomal lumen; endoplasmic reticulum lumen; endoplasmic reticulum

Molecular Function: protein binding; protein disulfide isomerase activity

Biological Process: protein folding; cell redox homeostasis; post-Golgi vesicle-mediated transport; apoptotic cell clearance; negative regulation of apoptosis
Product References and Citations for anti-TXNDC5 antibody
1. Sullivan D.C., et al. (2003) J Biol Chem. 278 (47) 47079-47088.

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