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anti-ESR2 antibody :: Mouse anti-Human Estrogen Receptor-beta Monoclonal Antibody

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Catalog # MBS418386
Unit / Price
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  0.1 mg  /  $445 +1 FREE 8GB USB
Product Name

Estrogen Receptor-beta (ESR2), Monoclonal Antibody

Full Product Name

Anti-Estrogen Receptor-beta Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9XSB5
Clonality
Monoclonal
Isotype
IgG1
Host
Mouse
Species Reactivity
Human
Purity/Purification
Purified by protein A affinity chromatography.
Form/Format
Liquid
Concentration
1ug/ul (lot specific)
Immunogen
Ni-NTA purified recombinant human ER-alpha (410-592aa) expressed in E Coli strain BL21 (DE3)
Storage Buffer
PBS, pH 7.4 with 0.05% sodium azide.
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Other Notes
Small volumes of anti-ESR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ESR2 antibody
The estrogen receptor (ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative splicing results in several ER mRNA transcripts, which differ primarily in their 5-prime untranslated regions. Two isoforms of the human ER, ERA and ER-beta, occur, each with distinct tissue and cell patterns of expression. Pelletier and El-Alfy (2000) studied the immunocytochemical localization of ESRA and ESRB in human reproductive tissues. In the ovary, ERB immunoreactivity was found in nuclei of granulosa cells of growing follicles at all stages from primary to mature follicles, interstitial gland, and germinal epithelium cells. Nuclear staining for ERA occurred in thecal, interstitial gland, and germinal epithelium cells. In the uterus, strong ERA immunoreactivity was detected in nuclei of epithelial, stromal, and muscle cells.
Applications Tested/Suitable for anti-ESR2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ESR2 antibody
Western Blot: 1: 100- 1: 500
IHC (P): 1: 100- 1: 500
IHC (F): 1: 100- 1: 500

Western Blot (WB) of anti-ESR2 antibody
anti-ESR2 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ESR2 antibody
anti-ESR2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ESR2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,032 Da[Similar Products]
NCBI Official Full Name
estrogen receptor beta
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
estrogen receptor beta
UniProt Protein Name
Estrogen receptor beta
UniProt Synonym Protein Names
Nuclear receptor subfamily 3 group A member 2
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
NR3A2; ER-beta  [Similar Products]
UniProt Comments for ESR2
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation.
Product References and Citations for anti-ESR2 antibody
1. Paech K. Science 1997, 277: 1508- 10. 2. Pertschuk LP¯Å'Cancer, 1996. 199677: 514- 9.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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