• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-CFH antibody :: Mouse anti-Human Factor H Monoclonal Antibody

Scan QR to view Datasheet
Catalog # MBS520287
Unit / Price
Scan QR to view Datasheet
  0.1 mg  /  $245 +1 FREE 8GB USB
anti-CFH antibody
Product Name

Factor H (CFH), Monoclonal Antibody

Popular Item
Full Product Name

Anti-Human Factor H (Biotin) (Clone: OX-24) (mouse IgG1)

Product Synonym Names
Factor H (Biotin) (Clone: OX-24) (mouse IgG1); Biotin Anti-Human Factor H Monoclonal Antibody
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (196621008..196716634). Location: 1q32
3D Structure
ModBase 3D Structure for P08603
Mouse IgG1
Clone Number
Species Reactivity
Factor H (Human Factor H)
Antibody Concentration: 0.1 mg/ml (lot specific)
Human complement Factor H
BALB/c mouse spleen cells
Fusion Partner
NS-O myeloma
100 ug Biotin conjugated Ig buffered in PBS, 0.02% NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml.
Preparation and Storage
Store at 4 degree C. For long term storage, aliquot and freeze unused portion at -20 degree C in volumes appropriate for single usage. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-CFH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CFH antibody
anti-human factor H (beta 1H) (139 kD) monoclonal antibody clone OX-24 inhibits the binding of factor H to surface bound C3. This antibody recognizes the human serum complement protein factor H and a 43- 49kD truncated form of factor H present at low levels (1-5ug/ml) in plasma and urine. Factor H occurs on the surface of some myeloid cell lines. This antibody cross-reacts with sera from other primates (rhesus monkey, cynomolgus monkey, African green monkey) in immunoprecipitation assay, but not with cow, pig, sheep, chick or rabbit sera3. Reported applications of this antibody include flow cytometry, ELISA, immunoprecipitation and Western Blotting.
Applications Tested/Suitable for anti-CFH antibody
NCBI/Uniprot data below describe general gene information for CFH. It may not necessarily be applicable to this product.
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
139,096 Da[Similar Products]
NCBI Official Full Name
factor H
NCBI Official Synonym Full Names
complement factor H
NCBI Official Symbol
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
complement factor H; beta-1H; factor H-like 1; beta-1-H-globulin; H factor 1 (complement); H factor 2 (complement); adrenomedullin binding protein; complement factor H, isoform b; age-related maculopathy susceptibility 1
UniProt Protein Name
Complement factor H
UniProt Synonym Protein Names
H factor 1
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
HF; HF1; HF2  [Similar Products]
UniProt Entry Name
NCBI Summary for CFH
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]
UniProt Comments for CFH
Function: Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.

Subcellular location: Secreted.

Tissue specificity: Expressed by the liver and secreted in plasma.

Involvement in disease: Basal laminar drusen (BLD) [MIM:126700]: Drusen are extracellular deposits that accumulate below the retinal pigment epithelium on Bruch membrane. Basal laminar drusen refers to an early adult-onset drusen phenotype that shows a pattern of uniform small, slightly raised yellow subretinal nodules randomly scattered in the macula. In later stages, these drusen often become more numerous, with clustered groups of drusen scattered throughout the retina. In time these small basal laminar drusen may expand and ultimately lead to a serous pigment epithelial detachment of the macula that may result in vision loss.Note: The gene represented in this entry is involved in disease pathogenesis.Complement factor H deficiency (CFHD) [MIM:609814]: A disorder that can manifest as several different phenotypes, including asymptomatic, recurrent bacterial infections, and renal failure. Laboratory features usually include decreased serum levels of factor H, complement component C3, and a decrease in other terminal complement components, indicating activation of the alternative complement pathway. It is associated with a number of renal diseases with variable clinical presentation and progression, including membranoproliferative glomerulonephritis and atypical hemolytic uremic syndrome.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.18 Ref.22 Ref.23 Ref.24 Ref.25 Ref.27 Ref.30 Ref.36Hemolytic uremic syndrome atypical 1 (AHUS1) [MIM:235400]: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Other genes may play a role in modifying the phenotype. Ref.19 Ref.20 Ref.21 Ref.26 Ref.28 Ref.29 Ref.30 Ref.38Age-related macular degeneration 4 (ARMD4) [MIM:610698]: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.40

Sequence similarities: Contains 20 Sushi (CCP/SCR) domains.

Sequence caution: The sequence CAB41739.1 differs from that shown. Reason: Frameshift at position 341.
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

Contact Us

Please fill out the form below and our representative will get back to you shortly.