• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Mouse anti-Human Factor Va, light chain, fragment E, 74kD Monoclonal Antibody

Scan QR to view Datasheet
Catalog # MBS604982
Unit / Price
  0.1 mg  /  $365 +1 FREE 8GB USB
anti-Factor Va, light chain, fragment E, 74kD antibody
Product Name

Factor Va, light chain, fragment E, 74kD, Monoclonal Antibody

Also Known As

Factor Va, light chain, fragment E, 74kD

Product Synonym Names
Anti -Factor Va, light chain, fragment E, 74kD
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Clonality
Monoclonal
Isotype
IgG1
Clone Number
3H368
Host
Mouse
Species Reactivity
Human
Specificity
Recognizes human Factor Va, light chain, (fragment E, 74,000). Does not react with intact Factor V.
Purity/Purification
Purified
Purified (>95% SDS-PAGE)
Form/Format
Supplied as a liquid, 50% glycerol, ddH2O.
Immunogen
Purified human Factor V
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Other Notes
Small volumes of anti-Factor Va, light chain, fragment E, 74kD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Factor V is a large, single chain, plasma glycoprotein which is an essential component in the blood coagulation cascade (1). During coagulation, the procofactor, factor V, is converted to the active cofactor, factor Va, via limited proteolysis by the serine protease a-thrombin (illustrated above), and less efficiently by factor Xa. The active cofactor is composed of an NH2-terminal derived heavy chain (Mr=94,000) and a COOH-terminal derived light chain (Mr=74,000) which remain non-covalently associated in the presence of calcium ions. Factor Va serves as a cofactor for the serine protease factor Xa. Factor Va and Xa assemble on a phospholipid surface in a non-covalent and calcium ion-dependent manner, to form the prothrombinase complex. The prothrombinase complex is responsible for the rapid conversion of the zymogen prothrombin to the active serine protease, a-thrombin. Assembly of the prothrombinase complex increases the rate at which prothrombin is converted to thrombin by nearly 300,000-fold relative to the rate with factor Xa alone. Down regulation of the prothrombinase complex is accomplished partly through the inactivation of factor Va by activated protein C.
ELISA (EL/EIA), Western Blot (WB), Radioimmunoassay (RIA)
Suitable for use in ELISA, RIA and Western Blot.
Dilution: Western Blot: 5ug/ml
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000