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anti-FSHB antibody :: anti-Human Follicle Stimulating Hormone (FSH) Monoclonal Antibody

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Catalog # MBS311615
Unit / Price
  1 mg  /  $335 +1 FREE 8GB USB
anti-FSHB antibody
Product Name

Follicle Stimulating Hormone (FSH) (FSHB), Monoclonal Antibody

Full Product Name

MAb to FSH

Product Synonym Names
Monoclonal Antibody to Human Follicle Stimulating Hormone (FSH)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 11; NC_000011.9 (30252563..30256824). Location: 11p13
OMIM
136530
3D Structure
ModBase 3D Structure for P01225
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
090-10243
Host
Host: Mouse
Source: Ascites
Species Reactivity
Human
Specificity
Follicle Stimulating Hormone (FSH)
FSH
Purity/Purification
>90% pure (SDS-PAGE). Protein A chromatography
Product is 0.2um filtered.
Form/Format
Purified, Liquid
Concentration
5.3mg/ml (OD280nm, E^1% = 14) (lot specific)
Affinity Constant
2 x 10^9
Buffer
10mM Phosphate, pH 7.4 containing 150mM Sodium chloride
Preservative
0.1% Sodium azide
Important Note
Centrifuge before opening to ensure complete recovery of vial contents.
Warnings
This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
Preparation and Storage
Short-term (up to 7 days) store at 2 to 8 degree C. Long term, aliquot and store at <-40 degree C. If aliquoted for long term storage, fill volume should be equal to or greater than 50% of the nominal fill volume of the vial used. Avoid repeated freeze/th
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-FSHB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-FSHB antibody
EIA/ELISA, Immunoassay Antibody Pairs
NCBI/Uniprot data below describe general gene information for FSHB. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,700 Da[Similar Products]
NCBI Official Full Name
follicle-stimulating hormone
NCBI Official Synonym Full Names
follicle stimulating hormone, beta polypeptide
NCBI Official Symbol
NCBI Protein Information
follitropin subunit beta; FSH-B; FSH-beta; OTTHUMP00000232881; OTTHUMP00000232882; follitropin beta chain; follitropin, beta chain; follicle-stimulating hormone beta subunit
UniProt Protein Name
Follitropin subunit beta
UniProt Synonym Protein Names
Follicle-stimulating hormone beta subunit; FSH-B; FSH-beta; Follitropin beta chain
Protein Family
UniProt Gene Name
UniProt Entry Name
FSHB_HUMAN
NCBI Summary for FSHB
The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq]
UniProt Comments for FSHB
Function: Stimulates development of follicle and spermatogenesis in the reproductive organs.

Subunit structure: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Subcellular location: Secreted.

Involvement in disease: Defects in FSHB are a cause of isolated follicle-stimulating hormone deficiency (IFSHD) [

MIM:229070]. Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men. Ref.15 Ref.16 Ref.17

Pharmaceutical use: Available under the names Gonal-F or Metrodin HP (Serono) and Puregon (Organon). Used in the treatment of infertility in women with proven hypopituitarism or who have not responded to clomifene; or in superovulation treatment for assisted conception (such as in vitro fertilization). Metrodin HP is also used in the treatment of hypogonadotrophic hypogonadism in men for the stimulation of spermatogenesis.

Sequence similarities: Belongs to the glycoprotein hormones subunit beta family.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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