NP_002028.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
tyrosine-protein kinase Fyn isoform a
NCBI Official Synonym Full Names
FYN proto-oncogene, Src family tyrosine kinase
NCBI Protein Information
tyrosine-protein kinase Fyn
UniProt Protein Name
Tyrosine-protein kinase Fyn
UniProt Synonym Protein Names
Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn
UniProt Synonym Gene Names
UniProt Entry Name
FYN_HUMAN
NCBI Summary for FYN
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]
UniProt Comments for FYN
Fyn: a tyrosine kinase of the Src family. Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC. Associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Three alternatively spliced isoforms have been described. Isoform 2 shows a greater ability to mobilize cytoplasmic calcium than isoform 1. Induced expression aids in cellular transformation and xenograft metastasis. In squamous cell carcinoma, Fyn transduces signals from EGFR and Src and is required for cell migration and invasiveness. Activity linked to migration in a murine melanoma model. Appears to block late stage development of neuroblastoma. Mouse knockout deficient in kindling response, a model for human epilepsy.
Protein type: Kinase, protein; Oncoprotein; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; TK group; Src family
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: extrinsic to internal side of plasma membrane; mitochondrion; postsynaptic density; plasma membrane; actin filament; cytosol; nucleus; endosome; lipid raft
Molecular Function: tubulin binding; CD8 receptor binding; ephrin receptor binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; peptide hormone receptor binding; G-protein-coupled receptor binding; protein-tyrosine kinase activity; T cell receptor binding; phosphoinositide 3-kinase binding; glycoprotein binding; CD4 receptor binding; ATP binding
Biological Process: axon guidance; central nervous system development; nerve growth factor receptor signaling pathway; T cell activation; viral reproduction; neuron migration; T cell receptor signaling pathway; protein amino acid phosphorylation; regulation of apoptosis; regulation of cell shape; calcium ion transport; forebrain development; ephrin receptor signaling pathway; feeding behavior; negative regulation of neuron apoptosis; cell differentiation; epidermal growth factor receptor signaling pathway; response to drug; platelet activation; cell migration; positive regulation of I-kappaB kinase/NF-kappaB cascade; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; dendrite morphogenesis; activated T cell proliferation; learning; regulation of defense response to virus by virus; regulation of cell proliferation; positive regulation of phosphoinositide 3-kinase cascade; detection of mechanical stimulus involved in sensory perception of pain; response to ethanol; T cell costimulation; innate immune response; negative regulation of protein catabolic process; vascular endothelial growth factor receptor signaling pathway; blood coagulation; leukocyte migration; transmembrane receptor protein tyrosine kinase signaling pathway
Product References and Citations for anti-FYN antibody
Kawakami T.,et al.Mol. Cell. Biol. 6:4195-4201(1986). Semba K.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:5459-5463(1986). Rigley K.,et al.J. Immunol. 154:1136-1145(1995). Goshima N.,et al.Nat. Methods 5:1011-1017(2008). Mungall A.J.,et al.Nature 425:805-811(2003).
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Products associated with anti-FYN antibody
Pathways associated with anti-FYN antibody
Diseases associated with anti-FYN antibody
Organs/Tissues associated with anti-FYN antibody
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