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anti-GnRHR antibody :: Mouse anti-Human GnRHR GnRHR Monoclonal Antibody

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Catalog # MBS530515
Unit / Price
  1 mg  /  $445 +1 FREE 8GB USB
anti-GnRHR antibody
Product Name

GnRHR, Monoclonal Antibody

Also Known As

GnRHR antibody

Product Synonym Names
Monoclonal GnRHR; Anti-GnRHR; Gonadotropin Releasing Hormone Receptor
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
328
OMIM
138850
3D Structure
ModBase 3D Structure for P30968
Clonality
Monoclonal
Isotype
IgG
Clone Number
M0201128
Host
Mouse
Species Reactivity
Human GnRHR
Form/Format
PBS, pH 7.5, with 0.1% NaN3.
Biological Significance
The gonadotropin-releasing hormone receptor (GNRHR), also known as the luteinizing hormone releasing hormone receptor (LHRHR), is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Immunogen
GnRHR antibody was raised in mouse using highly pure human gonadotropin releasing hormone receptor as the immunogen.
Preparation and Storage
Store at 4 degree C. DO NOT FREEZE.
Other Notes
Small volumes of anti-GnRHR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GnRHR antibody
Mouse monoclonal GnRHR antibody
Product Categories/Family for anti-GnRHR antibody
Applications Tested/Suitable for anti-GnRHR antibody
Immunohistochemistry (IHC), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for GnRHR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,727 Da
NCBI Official Full Name
gonadotropin releasing hormone receptor, partial
NCBI Official Synonym Full Names
gonadotropin-releasing hormone receptor
NCBI Official Symbol
GNRHR  [Similar Products]
NCBI Official Synonym Symbols
HH7; GRHR; LRHR; LHRHR; GNRHR1
  [Similar Products]
NCBI Protein Information
gonadotropin-releasing hormone receptor
UniProt Protein Name
Gonadotropin-releasing hormone receptor
UniProt Gene Name
GNRHR  [Similar Products]
UniProt Synonym Gene Names
GRHR; GnRH receptor; GnRH-R  [Similar Products]
UniProt Entry Name
GNRHR_HUMAN
NCBI Summary for GnRHR
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for GnRHR
GNRHR: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling. Defects in GNRHR are a cause of idiopathic hypogonadotropic hypogonadism (IHH). IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. Defects in GNRHR are a cause of fertile eunuch syndrome (FEUNS). Fertile eunuch syndrome is a mild phenotypic form of HH going with the presence of normal testicular size and some degree of spermatogenesis. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 4q21.2

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: gonadotropin-releasing hormone receptor activity; peptide binding

Biological Process: G-protein coupled receptor protein signaling pathway; multicellular organismal development

Disease: Hypogonadotropic Hypogonadism 7 With Or Without Anosmia
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-GnRHR antibody
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