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anti-GH1 antibody :: Mouse anti-Human Growth Hormone Monoclonal Antibody

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Catalog # MBS530284
Unit / Price
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  1 mg  /  $535 +1 FREE 8GB USB
anti-GH1 antibody
Product Name

Growth Hormone (GH1), Monoclonal Antibody

Full Product Name

Human Growth Hormone antibody

Product Synonym Names
Monoclonal Human Growth Hormone; Anti-Human Growth Hormone; hGH; Somatotropin
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
139250
3D Structure
ModBase 3D Structure for P01241
Clonality
Monoclonal
Isotype
IgG1
Clone Number
GhB9
Host
Mouse
Species Reactivity
Human
Purity/Purification
Human Growth Hormone antibody was purified by chromatography on protein G Sepharose.
Form/Format
Protein G purified and supplied in PBS, pH 7.4, 0.1 % NaN3.
Biological Significance
Growth hormone (GH) is a protein-based peptide hormone. It stimulates growth, cell reproduction and regeneration in humans and other animals. Growth hormone is a 191-amino acid, single-chain polypeptide that is synthesized, stored, and secreted by the somatotroph cells within the lateral wings of the anterior pituitary gland.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Immunogen
Human growth hormone antibody was raised in mouse using recombinant human growth hormone as the immunogen.
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of anti-GH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GH1 antibody
Mouse monoclonal Human Growth Hormone antibody
Product Categories/Family for anti-GH1 antibody
Applications Tested/Suitable for anti-GH1 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for GH1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,201 Da[Similar Products]
NCBI Official Full Name
growth hormone
NCBI Official Synonym Full Names
growth hormone 1
NCBI Official Symbol
NCBI Official Synonym Symbols
GH; GHN; GH-N; hGH-N; IGHD1B
  [Similar Products]
NCBI Protein Information
somatotropin
UniProt Protein Name
Somatotropin
UniProt Synonym Protein Names
Growth hormone; GH; GH-N; Growth hormone 1; Pituitary growth hormone
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
GH; GH-N  [Similar Products]
UniProt Entry Name
SOMA_HUMAN
NCBI Summary for GH1
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]
UniProt Comments for GH1
GH: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Defects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A); also known as pituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patients have an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH. Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenous GH. Defects in GH1 are the cause of Kowarski syndrome (KWKS); also known as pituitary dwarfism VI. Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2). IGHD2 is an autosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy. Belongs to the somatotropin/prolactin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Hormone

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; growth hormone receptor binding; growth factor activity; prolactin receptor binding; metal ion binding; hormone activity

Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of MAP kinase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of receptor internalization; positive regulation of JAK-STAT cascade; positive regulation of multicellular organism growth; glucose transport; JAK-STAT cascade; response to estradiol stimulus; positive regulation of tyrosine phosphorylation of Stat3 protein

Disease: Isolated Growth Hormone Deficiency, Type Ia; Isolated Growth Hormone Deficiency, Type Ib; Isolated Growth Hormone Deficiency, Type Ii; Kowarski Syndrome
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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