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anti-IL-33 antibody :: Mouse anti-Human IL-33 Monoclonal Antibody

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Catalog # MBS335425
Unit / Price
  0.5 mg  /  $530 +1 FREE 8GB USB
anti-IL-33 antibody
Product Name

IL-33, Monoclonal Antibody

Popular Item
Full Product Name

Mouse Anti-Human IL-33 Monoclonal Antibody, Azide Free Clone B-L33

Product Synonym Names
IL-33
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
608678
3D Structure
ModBase 3D Structure for O95760
Clonality
Monoclonal
Isotype
IgG1
Clone Number
B-L33
Host
Mouse
Species Reactivity
Human
Specificity
Recognises both natural and recombinant human IL-33
Purity/Purification
Ion exchange chromatography
Form/Format
Azide free
Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free
Antigen
IL-33
Hybridoma
Myeloma X63/AG.8653 x Balb/c lymph node cells
Immunisation
Recombinant human IL-33/NF-HEV
Preparation and Storage
Stable at +2-8 degree C for 12 months. For longer storage, freeze aliquots.
Other Notes
Small volumes of anti-IL-33 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-IL-33 antibody
ELISA (EIA)
Application Notes for anti-IL-33 antibody
Recognises soluble antigen
NCBI/Uniprot data below describe general gene information for IL-33. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,250 Da
NCBI Official Full Name
interleukin-33 isoform 3
NCBI Official Synonym Full Names
interleukin 33
NCBI Official Symbol
NCBI Official Synonym Symbols
DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26
  [Similar Products]
NCBI Protein Information
interleukin-33
UniProt Protein Name
Interleukin-33
UniProt Synonym Protein Names
Interleukin-1 family member 11; IL-1F11
UniProt Gene Name
UniProt Synonym Gene Names
C9orf26; IL1F11; NFHEV; IL-33; IL-1F11; NF-HEV  [Similar Products]
UniProt Entry Name
IL33_HUMAN
NCBI Summary for IL-33
IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 [PubMed 20926795]).[supplied by OMIM, Jan 2011]
UniProt Comments for IL-33
IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 9p24.1

Cellular Component: extracellular space; transport vesicle; chromosome; nucleus

Molecular Function: protein binding; cytokine activity

Biological Process: T-helper 2 type immune response; positive regulation of T-helper 2 type immune response; negative regulation of T-helper 1 type immune response; transcription, DNA-dependent; positive regulation of interleukin-6 production; positive regulation of immunoglobulin secretion; negative regulation of leukocyte migration; positive regulation of interleukin-4 production; negative regulation of immunoglobulin secretion; negative regulation of interferon-gamma production; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; positive regulation of macrophage activation; positive regulation of inflammatory response
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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