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anti-KLK7 antibody :: Mouse anti-Human Kallikrein 7 Monoclonal Antibody

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Catalog # MBS690083
Unit / Price
  0.1 mg  /  $490 +1 FREE 8GB USB
anti-KLK7 antibody
Product Name

Kallikrein 7 (KLK7), Monoclonal Antibody

Popular Item
Full Product Name

Mouse Anti-Human Kallikrein 7

Product Synonym Names
KLK7; hK7; SCCE; PRSS6
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 19; NC_000019.10 (50976479..50984064, complement). Location: 19q13.41
OMIM
604438
3D Structure
ModBase 3D Structure for P49862
Clonality
Monoclonal
Isotype
IgG2
Clone Number
(5J28)
Host
Mouse
Species Reactivity
Human
Specificity
This antibody was selected for its ability to detect human Kallikrenin-7.
Purity/Purification
Protein G chromatography
Form/Format
Lyophilized from a 0.2um filtered solution in phosphate-buffered saline (PBS).
Antibody Generation
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Kallikrein-7.
Antigen
Recombinant human Kallikrein-7
Buffer
PBS
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-KLK7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KLK7 antibody
The human tissue kallikrein (KLK) gene family contains 15 members that play important roles in cancer. Notably, kallikrein-1, also known as tissue kallikrein, cleaves kininogen to release the vasoactive kinin peptide, bradykinin or lysyl-bradykinin. Kallikrein-3, called prostate specific antigen (PSA), is an established tumor marker that aids in the diagnosis, staging, and follow up of prostate cancer. Kallikrein-4 is specifically expressed in the prostate and over-expressed in prostate cancer. Kallikrein-5 is widely expressed but found at high levels in skin, breast, brain and testis; over-expression is an indicator of poor prognosis in ovarian cancer. Kallikrein-8 is expressed in the brain and is a novel marker of ovarian and cervical cancer.
Applications Tested/Suitable for anti-KLK7 antibody
Western Blot (WB), Neutralization of Kalikrein-7: Yes
Application Notes for anti-KLK7 antibody
WB: Yes (1:500-1:1000)
Optimal dilutions should be determined by wach laboratory for each application.
NCBI/Uniprot data below describe general gene information for KLK7. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,525 Da[Similar Products]
NCBI Official Full Name
kallikrein-7 isoform 2
NCBI Official Synonym Full Names
kallikrein-related peptidase 7
NCBI Official Symbol
NCBI Official Synonym Symbols
hK7; SCCE; PRSS6
  [Similar Products]
NCBI Protein Information
kallikrein-7; signal protein; serine protease 6; stratum corneum chymotryptic enzyme; kallikrein 7 (chymotryptic, stratum corneum)
UniProt Protein Name
Kallikrein-7
UniProt Synonym Protein Names
Serine protease 6; Stratum corneum chymotryptic enzyme
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
PRSS6; SCCE; hK7; hSCCE  [Similar Products]
UniProt Entry Name
KLK7_HUMAN
NCBI Summary for KLK7
This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]
UniProt Comments for KLK7
Function: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. Ref.11

Catalytic activity: Cleavage of proteins with aromatic side chains in the P1 position.

Enzyme regulation: Inhibited by Zn2+ and Cu2+ at low micromolar concentrations. Inhibited by SERPINA12. Ref.11

Subcellular location: Secreted. Note: In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front. Ref.5

Tissue specificity: Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level). Ref.2 Ref.5

Induction: By estrogens and glucocorticoids in a breast carcinoma cell line. Ref.2 Ref.11

Sequence similarities: Belongs to the peptidase S1 family. Kallikrein subfamily.Contains 1 peptidase S1 domain.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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