NP_000212
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,730 Da
NCBI Official Full Name
ketohexokinase isoform a
NCBI Official Synonym Full Names
ketohexokinase (fructokinase)
NCBI Protein Information
ketohexokinase
UniProt Protein Name
Ketohexokinase
UniProt Synonym Protein Names
Hepatic fructokinase
UniProt Entry Name
KHK_HUMAN
NCBI Summary for KHK
This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for KHK
KHK iso2: Defects in KHK are the cause of fructosuria (FRUCT). Benign defect of intermediary metabolism. Belongs to the carbohydrate kinase PfkB family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transferase; Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.3
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: ketohexokinase activity; ATP binding
Biological Process: carbohydrate metabolic process; carbohydrate phosphorylation; pathogenesis; fructose catabolic process
Disease: Fructosuria, Essential
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Products associated with anti-KHK antibody
Pathways associated with anti-KHK antibody
Diseases associated with anti-KHK antibody
Organs/Tissues associated with anti-KHK antibody
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