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anti-KIF2C antibody :: Mouse anti-Human KIF2C Monoclonal Antibody

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Catalog # MBS120222
Unit / Price
  0.1 mg  /  $345 +1 FREE 8GB USB
Product Name

KIF2C, Monoclonal Antibody

Also Known As

Mouse monoclonal antibody Anti-Human KIF2C

Product Synonym Names
Homo sapiens kinesin family member 2C (KIF2C); MCAK; KNSL6
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
2896
OMIM
604538
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2488C3a
Host
Mouse
Species Reactivity
Human
Concentration
100 ug/ml (1.0 ml) (lot specific)
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Other Notes
Small volumes of anti-KIF2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KIF2C antibody
The protein encoded by this gene is a member of kinesin-like protein family. Proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation. [NCBI Entrez Gene Summary]
Applications Tested/Suitable for anti-KIF2C antibody
Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB), Flow Cytometry (FC/FACS)

Quality Control of anti-KIF2C antibody
Western blot analysis of immunized recombinant protein, using anti-KIF2C monoclonal antibody.
anti-KIF2C antibody Quality Control image
Quality Control #2 of anti-KIF2C antibody
Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-KIF2C antibody Quality Control #2 image
Western Blot (WB) of anti-KIF2C antibody
Detection of human KIF2C by Western blot.

Samples: Whole cell lysate (25 ug) from HeLa cells. [Lot No. 2488C3a-1]

Predicted molecular weight: 81 kDa
anti-KIF2C antibody Western Blot (WB) (WB) image
Flow Cytometry (FC/FACS) of anti-KIF2C antibody
HeLa cells were fixed in 2% paraformaldehyde/PBS and then permeabilized in 90% methanol. Cells were stained with anti-KIF2C mAb (shaded) or isotype control (unshaded) followed by Alexa Fluor(R) 488-conjugated goat anti-mouse IgG. [Lot No. 2488C3a-1]
anti-KIF2C antibody Flow Cytometry (FC/FACS) (FC/FACS) image
Immunocytochemistry (ICC) of anti-KIF2C antibody
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-KIF2C mAb. Nuclear was stained with Hoechst (blue fluorescence).[Lot No. 2488C3a-1]
anti-KIF2C antibody Immunocytochemistry (ICC) (ICC) image
NCBI/Uniprot data below describe general gene information for KIF2C. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
75,561 Da
NCBI Official Full Name
Homo sapiens kinesin family member 2C (KIF2C), transcript variant 1, mRNA
NCBI Official Synonym Full Names
kinesin family member 2C
NCBI Official Symbol
KIF2C  [Similar Products]
NCBI Official Synonym Symbols
MCAK; CT139; KNSL6
  [Similar Products]
NCBI Protein Information
kinesin-like protein KIF2C; kinesin-like protein 6; mitotic centromere-associated kinesin
UniProt Protein Name
Kinesin-like protein KIF2C
UniProt Synonym Protein Names
Kinesin-like protein 6; Mitotic centromere-associated kinesin; MCAK
Protein Family
UniProt Gene Name
KIF2C  [Similar Products]
UniProt Entry Name
KIF2C_HUMAN
NCBI Summary for KIF2C
This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Comments for KIF2C
KIF2C: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cancer Testis Antigen (CTA); Motor; Microtubule-binding

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: kinetochore; microtubule cytoskeleton; kinesin complex; membrane; cytoplasmic microtubule; nucleus; cytosol; chromosome, pericentric region

Molecular Function: centromeric DNA binding; microtubule plus-end binding; protein binding; ATPase activity; microtubule motor activity; ATP binding

Biological Process: cell proliferation; mitosis; cell division; metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule depolymerization; regulation of chromosome segregation; mitotic cell cycle; blood coagulation; mitotic metaphase plate congression; microtubule-based movement; establishment and/or maintenance of microtubule cytoskeleton polarity
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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