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anti-LIF antibody :: Mouse anti-Human LIF Monoclonal Antibody

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Catalog # MBS690701
Unit / Price
  0.1 mg  /  $490 +1 FREE 8GB USB
anti-LIF antibody
Product Name

LIF, Monoclonal Antibody

Popular Item
Also Known As

Mouse Anti-Human LIF

Product Synonym Names
LIF; CDF; DIA; HILDA; MLPLI
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
88
Chromosome Location
Chromosome: 22; NC_000022.11 (30240447..30257381, complement). Location: 22q12.2
OMIM
159540
3D Structure
ModBase 3D Structure for P15018
Clonality
Monoclonal
Isotype
IgG2
Clone Number
(6H31)
Host
Mouse
Species Reactivity
Human
Purity/Purification
Protein G chromatography
Form/Format
Lyophilized
Antibody Generation
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of LIF.
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
Buffer
PBS(sterile)
Remarks
This antibody was selected for its ability to detect human LIF.
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
Shipping: Cold packs
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-LIF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LIF antibody
Based on its helical structure, LIF (Leukemia Inhibitory Factor) is considered a member of the Interleukin-6 family of cytokines. Functionally, it has been implicated in a many physiological processes including development, hematopoiesis, bone metabolism, and inflammation. Some cell types known to express LIF include activated T cells, monocytes, astrocytes, osteoblasts, keratinocytes, regenerating skeletal muscle, mast cells, and fibroblasts.
Applications Tested/Suitable for anti-LIF antibody
Immunohistochemistry (IHC-P) - Paraffin, Neutralization
Application Notes for anti-LIF antibody
IHC(P): 1:20-1:100
Neutralization of LIF bioactivity: Yes
NCBI/Uniprot data below describe general gene information for LIF. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
leukemia inhibitory factor isoform 2
NCBI Official Synonym Full Names
leukemia inhibitory factor
NCBI Official Symbol
NCBI Official Synonym Symbols
CDF; DIA; HILDA; MLPLI
  [Similar Products]
NCBI Protein Information
leukemia inhibitory factor; D factor; human interleukin in DA cells; melanoma-derived LPL inhibitor; differentiation-inducing factor; hepatocyte-stimulating factor III; cholinergic differentiation factor; differentiation-stimulating factor; differentiation inhibitory activity
UniProt Protein Name
Leukemia inhibitory factor
UniProt Synonym Protein Names
Differentiation-stimulating factor; D factor; Melanoma-derived LPL inhibitor
UniProt Gene Name
UniProt Synonym Gene Names
HILDA; LIF; D factor; MLPLI  [Similar Products]
UniProt Entry Name
LIF_HUMAN
NCBI Summary for LIF
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
UniProt Comments for LIF
Function: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.

Subcellular location: Secreted.

Pharmaceutical use: In phase II clinical trial. The drug is being developed by Amrad to assist embryo implantation in women who have failed to become pregnant despite assisted reproductive technologies (ART).

Sequence similarities: Belongs to the LIF/OSM family.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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