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anti-LITAF antibody :: Mouse anti-Human LITAF Monoclonal Antibody

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Catalog # MBS200149
Unit / Price
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  0.05 mL  /  $240 +1 FREE 8GB USB
  0.1 mL  /  $315 +1 FREE 8GB USB
Western Blot (WB)
Product Name

LITAF, Monoclonal Antibody

Full Product Name

LITAF antibody

Product Synonym Names
lipopolysaccharide-induced TNF factor; PIG7; SIMPLE; FLJ38636; TP53I7
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
AF010312 mRNA
3D Structure
ModBase 3D Structure for Q99732
IgG2b, k
Clone Number
Species Reactivity
By protein-G affinity chromatography
Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
1mg/ml (lot specific)
Antigen Species
Recombinant human LITAF (1-161aa) purified from E. coli
Clone Note
Anti-human LITAF mAb, clone AT5C10, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human LITAF protein.
Preparation and Storage
Can be stored at 4 degree C.
For long term storage, aliquot and store at -20 degree C.
Avoid repeated freezing and thawing cycles.
Other Notes
Small volumes of anti-LITAF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LITAF antibody
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) mediates the expression of inflammatory cytokines such as TNF-alpha in Lipopolysaccharide-induced processes. LITAF binds to STAT6B, a member of the STAT6 family forming a complex on the TNF-alpha promoter that modulates TNF activity. High levels of expression of LITAF mRNA have been observed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen.
Product Categories/Family for anti-LITAF antibody
Applications Tested/Suitable for anti-LITAF antibody
ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-LITAF antibody
WB: 1:2000 ~ 3000.
Recommended starting dilution is 1:2000.

Western Blot (WB) of anti-LITAF antibody
The recombinant human LITAF protein (50ng) and Cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human LITAF antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: Recombinant protein Lane 2.: HeLa cell lysate Lane 3.: HepG2 cell lysate Lane 4.: A431 cell lysate Lane 5.: SW480 cell lysate
anti-LITAF antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for LITAF. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,824 Da
NCBI Official Full Name
lipopolysaccharide-induced tumor necrosis factor-alpha factor isoform 1
NCBI Official Synonym Full Names
lipopolysaccharide induced TNF factor
NCBI Official Symbol
LITAF  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
lipopolysaccharide-induced tumor necrosis factor-alpha factor
UniProt Protein Name
Lipopolysaccharide-induced tumor necrosis factor-alpha factor
UniProt Synonym Protein Names
Small integral membrane protein of lysosome/late endosome
UniProt Gene Name
LITAF  [Similar Products]
UniProt Synonym Gene Names
; LPS-induced TNF-alpha factor  [Similar Products]
NCBI Summary for LITAF
Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
UniProt Comments for LITAF
Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation (PubMed:23166352). Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades (PubMed:23166352). Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes (PubMed:23166352). Probably plays a role in regulating protein degradation via its interaction with NEDD4 (PubMed:15776429). May also contribute to the regulation of gene expression in the nucleus (PubMed:10200294, PubMed:15793005). Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines (PubMed:15793005). May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10 (PubMed:10200294, PubMed:15793005).
Product References and Citations for anti-LITAF antibody
Atucchi A, et al., (2006) Inflamm Bowel Dis 13 (1):120-121; Tang X, et al., (2005) Proc Natl Acad Sci USA 102 (14):5132-5137; Tang X, et al., (2003) Proc Natl Acad Sci USA 100 (7):4096-4101

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Pathways associated with anti-LITAF antibody
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