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anti-LMO1 antibody :: Mouse anti-Human LMO1 Monoclonal Antibody

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Catalog # MBS120420
Unit / Price
  0.1 mg  /  $345 +1 FREE 8GB USB
Product Name

LMO1, Monoclonal Antibody

Full Product Name

Mouse monoclonal antibody Anti-Human LMO1

Product Synonym Names
Homo sapiens LIM domain only 1 (rhombotin 1), mRNA (cDNA clone MGC:116691 IMAGE:40000076), complete cds.; RHOM1; TTG1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
186921
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
790C2a
Host
Mouse
Species Reactivity
Human
Concentration
100 ug/ml (1.0 ml) (lot specific)
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Other Notes
Small volumes of anti-LMO1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LMO1 antibody
LMO1 enocdes a cysteine-rich, two LIM domain transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more rarely than the related gene, LMO2 is disrupted.[NCBI Entrez Gene Summary]
Applications Tested/Suitable for anti-LMO1 antibody
Dot Blot (DB), Immunocytochemistry (ICC)

Quality Control of anti-LMO1 antibody
Western blot analysis of immunized recombinant protein, using anti-LMO1 monoclonal antibody.
anti-LMO1 antibody Quality Control image
Quality Control #2 of anti-LMO1 antibody
Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-LMO1 antibody Quality Control #2 image
Immunocytochemistry (ICC) of anti-LMO1 antibody
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-LMO1 mAb. [Lot No.790C2a-1]
anti-LMO1 antibody Immunocytochemistry (ICC) (ICC) image
NCBI/Uniprot data below describe general gene information for LMO1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,697 Da
NCBI Official Full Name
Homo sapiens LIM domain only 1 (rhombotin 1), mRNA
NCBI Official Synonym Full Names
LIM domain only 1 (rhombotin 1)
NCBI Official Symbol
NCBI Official Synonym Symbols
TTG1; RBTN1; RHOM1
  [Similar Products]
NCBI Protein Information
rhombotin-1; LIM domain only protein 1; LMO-1; T-cell translocation gene 1; T-cell translocation protein 1; cysteine-rich protein TTG-1
UniProt Protein Name
Rhombotin-1
UniProt Synonym Protein Names
Cysteine-rich protein TTG-1; LIM domain only protein 1; LMO-1; T-cell translocation protein 1
Protein Family
UniProt Gene Name
UniProt Entry Name
RBTN1_HUMAN
NCBI Summary for LMO1
This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012]
UniProt Comments for LMO1
LMO1: May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD.

Protein type: DNA-binding; Oncoprotein

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: nucleus

Molecular Function: zinc ion binding

Biological Process: positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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