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anti-LRP antibody :: Mouse LRP Monoclonal Antibody

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Catalog # MBS531812
Unit / Price
  0.05 mg  /  $430 +1 FREE 8GB USB
anti-LRP antibody
Product Name

LRP, Monoclonal Antibody

Also Known As

LRP antibody (515 kDa)

Product Synonym Names
Monoclonal LRP (515 kDa); Anti-LRP (515 kDa); Low Density LPR; LPR/alpha 2MR; Anti LRP (515 kDa); LRP-515antibody; LPR515; Human Liporotein Receptor Related Protein; LRP (515 kDa)
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
893
OMIM
605088
3D Structure
ModBase 3D Structure for Q14764
Clonality
Monoclonal
Isotype
IgG1
Clone Number
8G1
Host
Mouse
Species Reactivity
This antibody reacts with the 515 kDa a-chain of the Human LRP/a2MR which is expressed in a restricted spectrum of cell types
Specificity
Human LRP
Form/Format
Lyophilized. Reconstitute in 1 ml distilled water (final solution contains 0.5% BSA in PBS buffer, pH 7.4)
Biological Significance
Lipoprotein receptor-related proteins are a group of human proteins. A strong immunohistochemical reaction is seen in hepatocytes, tissue macrophages, subsets of neurones and astrocytes in the central nervous system, fibroblasts, smooth muscle cells, and monocyte-derived foam cells in atherosclerotic lesions in the arterial wall. The antibody can also be used for the characterization of a subset of myelomonocytic subtypes of chronic and acute leukemia (CD 91).
Immunogen
LRP antibody (515 kDa) was raised in mouse using human LRP/a2MR as the immunogen.
Preparation and Storage
Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles
Other Notes
Small volumes of anti-LRP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LRP antibody
Mouse monoclonal LRP antibody (515 kDa)
Product Categories/Family for anti-LRP antibody
Applications Tested/Suitable for anti-LRP antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-LRP antibody
IHC: 1:20
NCBI/Uniprot data below describe general gene information for LRP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
Molecular Weight
99,327 Da
NCBI Official Full Name
lrp
UniProt Protein Name
Major vault protein
UniProt Synonym Protein Names
Lung resistance-related protein
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
LRP; MVP  [Similar Products]
UniProt Entry Name
MVP_HUMAN
UniProt Comments for LRP
MVP: Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytoskeleton; membrane; perinuclear region of cytoplasm; cytoplasm; nuclear pore; ribonucleoprotein complex; nucleus

Molecular Function: protein binding; protein phosphatase binding; protein kinase binding

Biological Process: cell proliferation; protein transport; mRNA transport; negative regulation of protein amino acid autophosphorylation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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