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anti-MBP antibody :: Mouse anti-Human MBP MBP Monoclonal Antibody

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Catalog # MBS530522
Unit / Price
  1 mg  /  $610 +1 FREE 8GB USB
anti-MBP antibody
Product Name

MBP, Monoclonal Antibody

Also Known As

MBP antibody

Product Synonym Names
Monoclonal MBP; Anti-MBP; Anti MBP; Myelin Basic Protein; MBP
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
304
OMIM
159430
3D Structure
ModBase 3D Structure for P02686
Clonality
Monoclonal
Isotype
IgG
Clone Number
M0201109
Host
Mouse
Species Reactivity
Human MBP
Form/Format
PBS, pH 7.5, with 0.1% NaN3.
Biological Significance
Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the central nervous system (CNS).
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Immunogen
MBP antibody was raised in mouse using human MBP as the immunogen.
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of anti-MBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MBP antibody
Mouse monoclonal MBP antibody
Product Categories/Family for anti-MBP antibody
Applications Tested/Suitable for anti-MBP antibody
User optimized
NCBI/Uniprot data below describe general gene information for MBP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,343 Da
NCBI Official Full Name
Myelin basic protein
NCBI Official Synonym Full Names
myelin basic protein
NCBI Official Symbol
NCBI Protein Information
Golli-MBP; myelin basic protein
UniProt Protein Name
Myelin basic protein
UniProt Synonym Protein Names
Myelin A1 protein; Myelin membrane encephalitogenic protein
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
MBP_HUMAN
NCBI Summary for MBP
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]
UniProt Comments for MBP
MBP: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. Homodimer. Isoform 3 exists as a homodimer. MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. Belongs to the myelin basic protein family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 18q23

Cellular Component: compact myelin; internode region of axon; cell soma; plasma membrane; nucleus

Molecular Function: protein binding; structural constituent of myelin sheath; protease binding

Biological Process: myelination; response to mercury ion; synaptic transmission; substantia nigra development; central nervous system development; response to toxin; immune response; negative regulation of axonogenesis; axon ensheathment; response to progesterone stimulus; aging
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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