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Add To Compare List anti-MCL-1 antibody :: Mouse anti-Human MCL-1 Monoclonal Antibody Catalog # MBS9602360 Unit / Price 0.05 mL / $270 +1 FREE 8GB USB 0.1 mL / $335 +1 FREE 8GB USB 0.2 mL / $410 +1 FREE 8GB USB 5x0.2 mL / $1,670 +2 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name MCL-1, Monoclonal Antibody Popular Item Full Product Name MCL-1 Antibody Product Synonym Names Bcl 2 related protein EAT/mcl1; Bcl-2-like protein 3; Bcl-2-related protein EAT/mcl1; BCL2 related; Bcl2-L-3; BCL2L3; EAT; Induced myeloid leukemia cell differentiation protein Mcl 1; Induced myeloid leukemia cell differentiation protein Mcl-1; MCL 1; MCL1; MCL1-ES; mcl1/EAT; MCL1_HUMAN; MCL1L; MCL1S; MGC104264; MGC1839; Myeloid Cell Leukemia 1; Myeloid cell leukemia ES; Myeloid cell leukemia sequence 1; Myeloid cell leukemia sequence 1 BCL2 related; Myeloid cell leukemia sequence 1 isoform 1; OTTHUMP00000032794; OTTHUMP00000032795; TM Product Gene Name anti-MCL-1 antibody[Similar Products] Antibody/Peptide Pairs MCL-1 peptide (MBS9619814) is used for blocking the activity of MCL-1 antibody (MBS9602360) Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP 3D Structure ModBase 3D Structure for Q07820 Clonality Monoclonal Isotype IgG1 Host Mouse Species Reactivity Human Specificity MCL-1 antibody detects endogenous levels of total MCL-1 Purity/Purification Affinity-Chromatography Form/Format Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Concentration 1mg/ml (lot specific) Immunogen Purified recombinant fragment of human MCL-1 expressed in E. Coli Subcellular Location Membrane. Cytoplasm. Mitochondrion. Nucleus > Nucleoplasm. Cytoplasmic, associated with mitochondria. Tissue Specificity Expression increases early during phorbol ester-induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell line ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat shock-induced differentiation. Expression increases early during retinoic acid-induced differentiation. Preparation and Storage Store at -20 degree C. Stable for 12 months from date of receipt. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Supply Chain Verification Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire. Other Notes Small volumes of anti-MCL-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-MCL-1 antibody Description: Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identified as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin.Function: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.Subunit Structure: Interacts with HIF3A (via C-terminus domain) (By similarity). Interacts with BAD, BOK, BIK and BMF (By similarity). Interacts with PMAIP1 (PubMed:17389404). Interacts with BBC3 (By similarity). Isoform 1 interacts with BAX, BAK1 and TPT1 (PubMed:10837489, PubMed:12149273, PubMed:15077116). Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptotic BCL2-related proteins (PubMed:10837489). Interacts with RTL10/BOP (PubMed:23055042). Interacts with BCL2L11; may sequester BCL2L11 to prevent its pro-apoptotic activity (PubMed:10837489, PubMed:27013495, PubMed:17389404, PubMed:20562877).Post-translational Modifications: Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment. Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region. Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites. Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159.Similarity: Belongs to the Bcl-2 family. Applications Tested/Suitable for anti-MCL-1 antibody Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) Application Notes for anti-MCL-1 antibody ELISA: 1:10000WB: 1:500-1:2000IHC: 1:200-1:1000ICC: 1:200-1:1000 Western Blot (WB) of anti-MCL-1 antibody Figure 1: Western blot analysis using MCL1 mouse mAb against Hela (1), BCBL-1 (2), Jurkat (3) and HL60 (4) cell lysate. TOP NCBI/Uniprot data below describe general gene information for MCL-1. It may not necessarily be applicable to this product. NCBI GI # 309747067 NCBI GeneID 4170 NCBI Accession # NP_001184249.1 [Other Products] NCBI GenBank Nucleotide # NM_001197320.1 [Other Products] UniProt Primary Accession # Q07820 [Other Products] UniProt Secondary Accession # Q9HD91; Q9NRQ3; Q9NRQ4; Q9UHR7; Q9UHR8; Q9UHR9; Q9UNJ1; B2R6B2; D3DV03; D3DV04[Other Products] UniProt Related Accession # Q07820[Other Products] Molecular Weight Observed: 37 kDaPredicted: 38 kDa TOP NCBI Official Full Name induced myeloid leukemia cell differentiation protein Mcl-1 isoform 3 NCBI Official Synonym Full Names MCL1, BCL2 family apoptosis regulator NCBI Official Symbol MCL1 [Similar Products] NCBI Official Synonym Symbols TM; EAT; MCL1L; MCL1S; Mcl-1; BCL2L3; MCL1-ES; bcl2-L-3; mcl1/EAT [Similar Products] NCBI Protein Information induced myeloid leukemia cell differentiation protein Mcl-1 UniProt Protein Name Induced myeloid leukemia cell differentiation protein Mcl-1 UniProt Synonym Protein Names Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT UniProt Gene Name MCL1 [Similar Products] UniProt Synonym Gene Names BCL2L3; Bcl2-L-3 [Similar Products] TOP NCBI Summary for MCL-1 This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010] TOP UniProt Comments for MCL-1 Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. Research Articles on MCL-1 1. RaRF cross-talks with MCL1 during retinoic acid (RA)-induced leukemic myeloblast differentiation. MCL1 is upregulated by RA treatment upon RaRF depletion in acute promyelocytic leukemia cells. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-MCL-1 antibody Reference Product PubMed Publications BAX antibody >41 publications with MCL-1 and BAX CASP3 antibody >33 publications with MCL-1 and CASP3 BCL2L1 antibody >33 publications with MCL-1 and BCL2L1 PMAIP1 antibody >9 publications with MCL-1 and PMAIP1 BID antibody >8 publications with MCL-1 and BID BAD antibody >8 publications with MCL-1 and BAD BAK1 antibody >7 publications with MCL-1 and BAK1 BIK antibody >5 publications with MCL-1 and BIK BBC3 antibody >5 publications with MCL-1 and BBC3 PCNA antibody >5 publications with MCL-1 and PCNA Pathways associated with anti-MCL-1 antibody Products by Pathway Pathway Diagram Apoptosis Pathway antibodies Apoptosis Pathway Diagram Apoptosis Modulation And Signaling Pathway antibodies Apoptosis Modulation And Signaling Pathway Diagram Direct P53 Effectors Pathway antibodies Direct P53 Effectors Pathway Diagram E2F Transcription Factor Network Pathway antibodies E2F Transcription Factor Network Pathway Diagram HIF-1-alpha Transcription Factor Network Pathway antibodies HIF-1-alpha Transcription Factor Network Pathway Diagram IL-7 Signaling Pathway antibodies IL-7 Signaling Pathway Diagram IL6-mediated Signaling Events Pathway antibodies IL6-mediated Signaling Events Pathway Diagram PI3K-Akt Signaling Pathway antibodies PI3K-Akt Signaling Pathway Diagram PI3K-Akt Signaling Pathway antibodies PI3K-Akt Signaling Pathway Diagram Diseases associated with anti-MCL-1 antibody Disease Name Pubmed Publications Neoplasms Antibodies >133 publications with MCL-1 and Neoplasms Multiple Myeloma Antibodies >15 publications with MCL-1 and Multiple Myeloma Drug Toxicity Antibodies >13 publications with MCL-1 and Drug Toxicity Lung Diseases Antibodies >12 publications with MCL-1 and Lung Diseases Necrosis Antibodies >11 publications with MCL-1 and Necrosis Adenocarcinoma Antibodies >10 publications with MCL-1 and Adenocarcinoma Lung Neoplasms Antibodies >10 publications with MCL-1 and Lung Neoplasms Nervous System Diseases Antibodies >6 publications with MCL-1 and Nervous System Diseases Liver Diseases Antibodies >5 publications with MCL-1 and Liver Diseases Sarcoma Antibodies >5 publications with MCL-1 and Sarcoma Organs/Tissues associated with anti-MCL-1 antibody Organ/Tissue Name Pubmed Publications Blood Antibodies >38 publications with MCL-1 and Blood Bone Antibodies >22 publications with MCL-1 and Bone Lung Antibodies >19 publications with MCL-1 and Lung Bone Marrow Antibodies >14 publications with MCL-1 and Bone Marrow Vascular Antibodies >12 publications with MCL-1 and Vascular Brain Antibodies >10 publications with MCL-1 and Brain Liver Antibodies >6 publications with MCL-1 and Liver Lymph Node Antibodies >6 publications with MCL-1 and Lymph Node Lymph Antibodies >5 publications with MCL-1 and Lymph Heart Antibodies >5 publications with MCL-1 and Heart TOP © 2006-24 MyBioSource.com. 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