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anti-ABCC3 antibody :: Mouse anti-Human MRP3 Monoclonal Antibody

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Catalog # MBS632159
Unit / Price
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  1 mL  /  $700 +1 FREE 8GB USB
Test Data
Product Name

MRP3 (ABCC3), Monoclonal Antibody

Popular Item
Full Product Name

MRP3 (Multidrug Resistance-associated Protein 3, ABC31, ATP Binding Cassette Sub-family C Member 3, ATP-binding Cassette Sub-family C (CFTR/MRP) Member 3, ABCC3, Canalicular Multispecific Organic Anion Transporter 2, CMOAT2, DKFZp686E22157, EST90757, MLP2

Product Synonym Names
Anti -MRP3 (Multidrug Resistance-associated Protein 3, ABC31, ATP Binding Cassette Sub-family C Member 3, ATP-binding Cassette Sub-family C (CFTR/MRP) Member 3, ABCC3, Canalicular Multispecific Organic Anion Transporter 2, CMOAT2, DKFZp686E22157, EST90757, MLP2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 17; NC_000017.10 (48712218..48769063). Location: 17q22
OMIM
604323
3D Structure
ModBase 3D Structure for O15438
Clonality
Monoclonal
Isotype
IgG1
Clone Number
M3II-9
Host
Mouse
Species Reactivity
Human
Specificity
Recognizes an internal epitope of MRP3. Species Crossreactivity: human. Does not crossreact with human MDR1, MRP1, MRP2 or MRP5 gene products.
Purity/Purification
Supernatant
Supernatant
Form/Format
Supplied as a liquid, 0.7% BSA, 0.1% sodium azide.
Immunogen
Bacterial fusion protein corresponding to aa830-949 of MRP3.
Hybridoma
Sp2/0 myeloma cells with lymph node cells from Balb/c mice.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-ABCC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABCC3 antibody
MRP3 is a 190-200kD transmembrane protein that is closely related to the multidrug resistance protein MRP1. M4688-23B has potential vaule for the detection of MRP3-mediated drug-resistance in human tumor samples.
Applications Tested/Suitable for anti-ABCC3 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)
Application Notes for anti-ABCC3 antibody
Suitable for use in Western Blot, Immunocytochemistry, Immunohistochemistry and Flow Cytometry.
Dilution: Western Blot: 1:20-1:50 using a secondary antibody conjugated to HRP.
Immnocytochemistry: 1:20-1:50 on acetone or formaldehyde fixed cytospin preparations.
Immunohistochemistry (Frozen): 1:20 on acetone fixed frozen sections.

Test Data of anti-ABCC3 antibody
anti-ABCC3 antibody Test Data image
NCBI/Uniprot data below describe general gene information for ABCC3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
169,343 Da[Similar Products]
NCBI Official Full Name
MRP3
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
NCBI Official Symbol
ABCC3  [Similar Products]
NCBI Official Synonym Symbols
MLP2; MRP3; ABC31; MOAT-D; cMOAT2; EST90757; DKFZp686E22157
  [Similar Products]
NCBI Protein Information
canalicular multispecific organic anion transporter 2; OTTHUMP00000221667; OTTHUMP00000221668; OTTHUMP00000221670; multidrug resistance associated protein; multidrug resistance-associated protein 3; ATP-binding cassette sub-family C member 3; multi-specific organic anion transporter D; canicular multispecific organic anion transporter
UniProt Protein Name
Canalicular multispecific organic anion transporter 2
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 3; Multi-specific organic anion transporter D; MOAT-D; Multidrug resistance-associated protein 3
Protein Family
UniProt Gene Name
ABCC3  [Similar Products]
UniProt Synonym Gene Names
CMOAT2; MLP2; MRP3  [Similar Products]
UniProt Entry Name
MRP3_HUMAN
NCBI Summary for ABCC3
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq]
UniProt Comments for ABCC3
ABCC3: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ABC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q22

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; organic anion transmembrane transporter activity; ATP binding

Biological Process: bile acid and bile salt transport; transport; bile acid metabolic process; transmembrane transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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