NP_002448.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
mucin-2
NCBI Official Synonym Full Names
mucin 2, oligomeric mucus/gel-forming
NCBI Protein Information
mucin-2
UniProt Protein Name
Mucin-2
UniProt Synonym Protein Names
Intestinal mucin-2
UniProt Synonym Gene Names
UniProt Entry Name
MUC2_HUMAN
NCBI Summary for MUC2
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
UniProt Comments for MUC2
MUC2: Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
Protein type: Secreted, signal peptide; Extracellular matrix; Secreted
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: Golgi lumen
Molecular Function: protein binding
Biological Process: maintenance of gastrointestinal epithelium; O-glycan processing
Product References and Citations for anti-MUC2 antibody
Xing PX, et. al. Journal of the National Cancer Institute, 1992, 84(9):699-703
Research Articles on MUC2
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Products associated with anti-MUC2 antibody
Pathways associated with anti-MUC2 antibody
Diseases associated with anti-MUC2 antibody
Organs/Tissues associated with anti-MUC2 antibody
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