NP_005016.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,427 Da
NCBI Official Full Name
neuroserpin
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade I (neuroserpin), member 1
NCBI Protein Information
neuroserpin; PI-12; serpin I1; peptidase inhibitor 12; serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1
UniProt Protein Name
Neuroserpin
UniProt Synonym Protein Names
Peptidase inhibitor 12; PI-12; Serpin I1
UniProt Synonym Gene Names
UniProt Entry Name
NEUS_HUMAN
NCBI Summary for SERPINI1
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for SERPINI1
SERPINI1: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator. Defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B). FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin. Belongs to the serpin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3q26.1
Cellular Component: extracellular space
Molecular Function: serine-type endopeptidase inhibitor activity
Biological Process: regulation of cell adhesion; central nervous system development; peripheral nervous system development
Disease: Encephalopathy, Familial, With Neuroserpin Inclusion Bodies
Research Articles on SERPINI1
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Products associated with anti-SERPINI1 antibody
Pathways associated with anti-SERPINI1 antibody
Diseases associated with anti-SERPINI1 antibody
Organs/Tissues associated with anti-SERPINI1 antibody
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