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anti-NGFR antibody :: Mouse anti-Human NGFR Monoclonal Antibody

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Catalog # MBS370134
Unit / Price
  5 Control Slides  /  $130 +1 FREE 8GB USB
  0.1 mL (Concentrate)  /  $190 +1 FREE 8GB USB
  3 ml (Prediluted)  /  $210 +1 FREE 8GB USB
  7 ml (Prediluted)  /  $315 +1 FREE 8GB USB
  0.5 mL (Concentrate)  /  $440 +1 FREE 8GB USB
  15 ml (Prediluted)  /  $540 +1 FREE 8GB USB
  1 mL (Concentrate)  /  $730 +1 FREE 8GB USB
Product Name

NGFR, Monoclonal Antibody

Also Known As

NGFR

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 17; NC_000017.10 (47572655..47592382). Location: 17q21-q22
OMIM
162010
3D Structure
ModBase 3D Structure for P08138
Clonality
Monoclonal
Isotype
IgG1
Clone Number
NGFR/c10
Host
Mouse
Species Reactivity
Human
Form/Format
NGFR is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Control
Breast, CNS Tumors
Localization
Cytoplasmic
Reactivity Note
Paraffin, Frozen
Preparation and Storage
Store at 2 to 8 degree C in the dark.
ISO Certification
Manufactured in an ISO 13485:2016 Certified Laboratory.
Other Notes
Small volumes of anti-NGFR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NGFR antibody
NGFR (Nerve Growth Factor Receptor), also termed p75 or CD271, is the low-affinity NGFR (LNGFR) which binds NGF and other neurotrophins, including BDNF, NT3 and NT4/5 with similar low-affinity. NGFR p75 is a 75 kD transmembrane glycoprotein that is mainly expressed in Schwann cells and neurons and in a variety of non-neuronal cells. NGFR p75 is necessary for regulating neuronal growth, migration, differentiation and cell death during development of the central and peripheral nervous system. NGFR p75 plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of NGFR p75 by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase/ceramide pathway, the ICE-like proteases and the JNK pathway. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells). NGFR is expressed not only in sympathetic and sensory neurons, but also in various neural crest cell or tumor derivatives such as melanocytes, Melanomas, Neuroblastomas, Pheochromocytomas, Neurofibromas, and neurotized nevi (Type C melanocytes). It is now apparent that expression of NGFR is ubiquitous and not limited to the nervous system. Studies in Prostate and Urothelial Cancer suggest that NGFR may act as a tumor suppressor, negatively regulating cell growth and proliferation. NGFR labels the myoepithelial cells of breast ducts and intralobular fibroblasts of breast ducts and, thus, aids in the diagnosis of malignancy in the breast.

Dilution Information of anti-NGFR antibody
anti-NGFR antibody Dilution Information image
Immunohistochemistry (IHC) of anti-NGFR antibody
anti-NGFR antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for NGFR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,183 Da
NCBI Official Full Name
nerve growth factor receptor (TNFR superfamily, member 16)
NCBI Official Synonym Full Names
nerve growth factor receptor
NCBI Official Symbol
NCBI Official Synonym Symbols
CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR
  [Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 16; p75 ICD; NGF receptor; OTTHUMP00000220318; OTTHUMP00000220319; TNFR superfamily, member 16; low affinity nerve growth factor receptor; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 16
UniProt Synonym Protein Names
Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD
UniProt Gene Name
UniProt Synonym Gene Names
TNFRSF16  [Similar Products]
UniProt Entry Name
TNR16_HUMAN
NCBI Summary for NGFR
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq]
UniProt Comments for NGFR
Function: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Ref.11

Subunit structure: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1

By similarity. Interacts with LINGO1. Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11

Subcellular location: Membrane; Single-pass type I membrane protein.

Domain: Death domain is responsible for interaction with RANBP9.The extracellular domain is responsible for interaction with NTRK1

Post-translational modification: N- and O-glycosylated. Ref.12O-linked glycans consist of Gal1-3GalNAc core elongated by 1 or 2 NeuNAc.Phosphorylated on serine residues.

Sequence similarities: Contains 1 death domain.Contains 4 TNFR-Cys repeats.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-NGFR antibody
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