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anti-NMNAT1 antibody :: Mouse anti-Human NMNAT1 Monoclonal Antibody

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Catalog # MBS120521
Unit / Price
  0.1 mg  /  $345 +1 FREE 8GB USB
Product Name

NMNAT1, Monoclonal Antibody

Popular Item
Also Known As

Mouse monoclonal antibody Anti-Human NMNAT1

Product Synonym Names
Homo sapiens nicotinamide nucleotide adenylyltransferase 1 (NMNAT1), mRNA; NMNAT;PNAT1;PNAT-1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
3781
OMIM
608553
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2642C5a
Host
Mouse
Species Reactivity
Human
Concentration
100 ug/ml (1.0 ml) (lot specific)
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Other Notes
Small volumes of anti-NMNAT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NMNAT1 antibody
The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca(2+) signaling pathways. NMNAT (EC 2.7.7.1) is a central enzyme in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD (Zhang et al., 2003 [PubMed 12574164]).[supplied by OMIM][NCBI Entrez Gene Summary]
Applications Tested/Suitable for anti-NMNAT1 antibody
Dot Blot (DB), Immunocytochemistry (ICC)

Quality Control of anti-NMNAT1 antibody
Left: Western blot analysis of immunized recombinant protein, using anti-NMNAT1 monoclonal antibody. Right: CBB staining of immunized recombinant protein.
anti-NMNAT1 antibody Quality Control image
Quality Control #2 of anti-NMNAT1 antibody
Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-NMNAT1 antibody Quality Control #2 image
NCBI/Uniprot data below describe general gene information for NMNAT1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,932 Da
NCBI Official Full Name
Homo sapiens nicotinamide nucleotide adenylyltransferase 1 (NMNAT1), transcript variant 1, mRNA
NCBI Official Synonym Full Names
nicotinamide nucleotide adenylyltransferase 1
NCBI Official Symbol
NMNAT1  [Similar Products]
NCBI Official Synonym Symbols
LCA9; NMNAT; PNAT1
  [Similar Products]
NCBI Protein Information
nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; NMN adenylyltransferase 1; NMN/NaMN adenylyltransferase 1; nicotinamide mononucleotide adenylyltransferase 1; nicotinamide-nucleotide adenylyltransferase 1; nicotinate-nucleotide adenylyltransferase 1; pyridine nucleotide adenylyltransferase 1
UniProt Protein Name
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
UniProt Synonym Protein Names
Nicotinamide-nucleotide adenylyltransferase 1; NMN adenylyltransferase 1; Nicotinate-nucleotide adenylyltransferase 1; NaMN adenylyltransferase 1
UniProt Gene Name
NMNAT1  [Similar Products]
UniProt Entry Name
NMNA1_HUMAN
NCBI Summary for NMNAT1
This gene encodes an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). The encoded enzyme is one of several nicotinamide nucleotide adenylyltransferases, and is specifically localized to the cell nucleus. Activity of this protein leads to the activation of a nuclear deacetylase that functions in the protection of damaged neurons. Mutations in this gene have been associated with Leber congenital amaurosis 9. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14, and 15. [provided by RefSeq, Jul 2014]
UniProt Comments for NMNAT1
NMNAT1: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults. Belongs to the eukaryotic NMN adenylyltransferase family.

Protein type: EC 2.7.7.1; Transferase; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.7.7.18

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity; ATP binding

Biological Process: NAD biosynthetic process; vitamin metabolic process; NAD metabolic process; water-soluble vitamin metabolic process

Disease: Leber Congenital Amaurosis 9
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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 Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies  Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
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 Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway antibodies  Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway Diagram
 Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway antibodies  Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway Diagram
 Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway antibodies  Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway Diagram
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