• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-NR4A2 antibody :: Mouse anti-Human NR4A2 Monoclonal Antibody

Scan QR to view Datasheet
Catalog # MBS120305
Unit / Price
  0.1 mg  /  $345 +1 FREE 8GB USB
Product Name

NR4A2, Monoclonal Antibody

Popular Item
Also Known As

Mouse monoclonal antibody Anti-Human NR4A2

Product Synonym Names
Homo sapiens nuclear receptor subfamily 4, group A, member 2; NOT; RNR1; HZF-3; NURR1; TINUR
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
3546
OMIM
601828
Clonality
Monoclonal
Isotype
IgG1
Clone Number
447C2a
Host
Mouse
Species Reactivity
Human
Concentration
100 ug/ml (1.0 ml) (lot specific)
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Other Notes
Small volumes of anti-NR4A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NR4A2 antibody
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full length nature has not been determined. [NCBI Entrez Gene Summary]
Applications Tested/Suitable for anti-NR4A2 antibody
Dot Blot (DB), Western Blot (WB)

Quality Control of anti-NR4A2 antibody
Western blot analysis of immunized recombinant protein, using anti-NR4A2 monoclonal antibody.
anti-NR4A2 antibody Quality Control image
Quality Control #2 of anti-NR4A2 antibody
Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-NR4A2 antibody Quality Control #2 image
Western Blot (WB) of anti-NR4A2 antibody
Detection of human NR4A2 by Western blot.

Samples: Whole cell lysate (25 ug) from HeLa cells. [Lot No. 447C2a-1]

Predicted molecular weight: 66 kDa
anti-NR4A2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for NR4A2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,809 Da
NCBI Official Full Name
Homo sapiens nuclear receptor subfamily 4, group A, member 2 (NR4A2), mRNA
NCBI Official Synonym Full Names
nuclear receptor subfamily 4, group A, member 2
NCBI Official Symbol
NR4A2  [Similar Products]
NCBI Official Synonym Symbols
NOT; RNR1; HZF-3; NURR1; TINUR
  [Similar Products]
NCBI Protein Information
nuclear receptor subfamily 4 group A member 2; NGFI-B/nur77 beta-type transcription factor homolog; T-cell nuclear receptor NOT; immediate-early response protein NOT; intermediate-early receptor protein; nuclear receptor related 1; nur related protein-1, human homolog of; orphan nuclear receptor NR4A2; orphan nuclear receptor NURR1; transcriptionally inducible nuclear receptor related 1; transcriptionally-inducible nuclear receptor
UniProt Protein Name
Nuclear receptor subfamily 4 group A member 2
UniProt Synonym Protein Names
Immediate-early response protein NOT; Orphan nuclear receptor NURR1; Transcriptionally-inducible nuclear receptor
UniProt Gene Name
NR4A2  [Similar Products]
UniProt Entry Name
NR4A2_HUMAN
NCBI Summary for NR4A2
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for NR4A2
NR4A2: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Belongs to the nuclear hormone receptor family. NR4 subfamily.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 2q22-q23

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: ligand-dependent nuclear receptor activity; protein binding; zinc ion binding; protein heterodimerization activity; steroid hormone receptor activity

Biological Process: positive regulation of catalytic activity; adult locomotory behavior; neuron migration; dopamine biosynthetic process; response to insecticide; signal transduction; neuron maturation; post-embryonic development; regulation of respiratory gaseous exchange; general adaptation syndrome; negative regulation of neuron apoptosis; transcription initiation from RNA polymerase II promoter; response to inorganic substance; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; death; regulation of dopamine metabolic process; response to amphetamine; central nervous system projection neuron axonogenesis; habenula development; cellular response to extracellular stimulus; response to hypoxia; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; gene expression

Disease: Parkinson Disease, Late-onset
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000