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anti-ORC6 antibody :: Mouse anti-Human ORC6L Monoclonal Antibody

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Catalog # MBS604166
Unit / Price
  0.1 mg  /  $565 +1 FREE 8GB USB
anti-ORC6 antibody
Product Name

ORC6L, Monoclonal Antibody

Full Product Name

ORC6L (Origin Recognition Complex Subunit 6-like)

Product Synonym Names
Anti -ORC6L (Origin Recognition Complex Subunit 6-like)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 16; NC_000016.9 (46723558..46732306). Location: 16q12
OMIM
607213
3D Structure
ModBase 3D Structure for Q9Y5N6
Clonality
Monoclonal
Isotype
IgG1
Clone Number
8C256
Host
Mouse
Species Reactivity
Human
Specificity
Recognizes human ORC6L.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.
Immunogen
Partial sequence of recombinant full-length protein to human ORC6L
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-ORC6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ORC6 antibody
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown that this protein and and ORC1L are loosely associated with the core complex consisting of ORC2L, -3L, -4L and -5L. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.
Product Categories/Family for anti-ORC6 antibody
Applications Tested/Suitable for anti-ORC6 antibody
Western Blot (WB)
Application Notes for anti-ORC6 antibody
Suitable for use in Western Blot.
NCBI/Uniprot data below describe general gene information for ORC6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,107 Da[Similar Products]
NCBI Official Full Name
origin recognition complex subunit 6
NCBI Official Synonym Full Names
origin recognition complex, subunit 6
NCBI Official Symbol
NCBI Official Synonym Symbols
ORC6L
  [Similar Products]
NCBI Protein Information
origin recognition complex subunit 6
UniProt Protein Name
Origin recognition complex subunit 6
UniProt Gene Name
UniProt Synonym Gene Names
ORC6L  [Similar Products]
UniProt Entry Name
ORC6_HUMAN
NCBI Summary for ORC6
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]
UniProt Comments for ORC6
ORC6L: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4. Belongs to the ORC6 family.

Protein type: DNA replication

Chromosomal Location of Human Ortholog: 16q12

Cellular Component: nucleoplasm; membrane; plasma membrane; nuclear origin of replication recognition complex; nucleus; origin recognition complex

Molecular Function: protein binding; DNA binding

Biological Process: mitotic cell cycle; DNA-dependent DNA replication; DNA replication; G1/S transition of mitotic cell cycle

Disease: Meier-gorlin Syndrome 3
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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