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anti-PAX7 antibody :: Mouse anti-Human PAX7 Monoclonal Antibody

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Catalog # MBS438996
Unit / Price
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  0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
  0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
  0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
Product Name

PAX7, Monoclonal Antibody

Popular Item
Full Product Name

PAX7 (Rhabdomyosarcoma Marker) Mouse Monoclonal Antibody

Product Synonym Names
HUP1; Paired box gene 7; Paired box homeotic gene 7; Paired domain gene HuP1; PAX7 transcriptional factor; PAX7/FKHR fusion gene; PAX7B; RMS2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
167410
3D Structure
ModBase 3D Structure for P23759
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
PAX7/1187
Host
Mouse
Species Reactivity
Human
Specificity
The Pax gene family of nuclear transcription factors is comprised of nine members that function during embryogenesis to regulate the temporal and position-dependent differentiation of cells. In addition, the family is involved in a variety of signal transduction pathways in the adult organism. Mutations in the Pax family of proteins have been linked to disease and cancer in humans. Pax-7 is a protein specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization reveals that Pax-7 is also expressed in satellite cells residing in adult muscle. A chromosomal aberration in the gene encoding Pax-7 causes rhabdomyosarcoma 2 (RMS2) (also called alveolar rhabdomyosarcoma).
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Cellular Localization
Nuclear
Immunogen
Recombinant fragment (aa300-600) of human PAX7 protein
Hu-Chromosome Location
1p36.13
Positive Control
Rhabdomyosarcoma (RMS) or Testicular Carcinoma
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Other Notes
Small volumes of anti-PAX7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PAX7 antibody
Immunohistochemistry (IHC) Formalin
Application Notes for anti-PAX7 antibody
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris Buffer with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)

Immunohistochemistry (IHC) of anti-PAX7 antibody
Formalin-fixed, paraffin-embedded human Rhabdomyosarcoma stained with PAX7 Monoclonal Antibody (PAX7/1187).
anti-PAX7 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-PAX7 antibody
Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with PAX7 Monoclonal Antibody (PAX7/1187).
anti-PAX7 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PAX7. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57kDa
NCBI Official Full Name
paired box protein Pax-7 isoform 3
NCBI Official Synonym Full Names
paired box 7
NCBI Official Symbol
NCBI Official Synonym Symbols
HUP1; RMS2; PAX7B
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NCBI Protein Information
paired box protein Pax-7
UniProt Protein Name
Paired box protein Pax-7
UniProt Synonym Protein Names
HuP1
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
PAX7_HUMAN
NCBI Summary for PAX7
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
UniProt Comments for PAX7
PAX7: Probable transcription factor. May have a role in myogenesis. Defects in PAX7 are a cause of rhabdomyosarcoma type 2 (RMS2). It is a form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchimal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. A chromosomal aberration involving PAX7 is found in rhabdomyosarcoma. Translocation t(1;13)(p36;q14) with FOXO1. The resulting protein is a transcriptional activator. Belongs to the paired homeobox family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding; Oncoprotein

Chromosomal Location of Human Ortholog: 1p36.13

Molecular Function: transcription factor activity

Biological Process: anatomical structure morphogenesis; negative regulation of apoptosis

Disease: Rhabdomyosarcoma 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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