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anti-PEG10 antibody :: anti-Human PEG10 Monoclonal Antibody

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Catalog # MBS475079
Unit / Price
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  0.1 mL  /  $335 +1 FREE 8GB USB
Product Name

PEG10, Monoclonal Antibody

Popular Item
Full Product Name

Anti-PEG10 Mouse mAb

Product Synonym Names
AA407948; Edr; Embryonal carcinoma differentiation regulated; Embryonal carcinoma differentiation-regulated protein; HB 1; HB1; KIAA1051; Mammalian retrotransposon-derived protein 2; Mar2; Mart2; MEF3 like 1; MEF3-like protein 1; MEF3L; MEF3L1; MyEF 3; Myelin expression factor 3-like protein 1; Paternally expressed 10; Paternally expressed gene 10 ORF1; Paternally expressed gene 10 protein; Peg10; PEG10 protein; PEG10_HUMAN; Putative uncharacterized protein PEG10; Retrotransposon gag domain containing 3; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; Retrotransposon-derived protein PEG10; RGAG3; Ty3/Gypsy-like protein
Product Synonym Gene Name
EDR; HB-1; Mar2; MEF3L; Mart2; RGAG3[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
AB049834 mRNA
3D Structure
ModBase 3D Structure for Q86TG7
Clonality
Monoclonal
Isotype
IgG1
Clone Number
1E2-F12-C12
Host
Mouse
Source: Human
Species Reactivity
Human
Purity/Purification
Affinity Purified
Form/Format
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%, glycerol
Concentration
1mg/ml (lot specific)
Immunogen
Purified recombinant human PEG10 protein fragments expressed in E Coli.
Sensitivity
This antibody detects endogenous levels of PEG10 and does not cross-react with related proteins.
Sequence Similarities
Contains 1 CCHC-type zinc finger.
Subunit Structure
Interacts with ALK1, SIAH1 and SIAH2.
Subcellular Location
Nucleus. Cytoplasm
Other Notes
Small volumes of anti-PEG10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PEG10 antibody
Entrez Summary: This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas. [provided by RefSeq, May 2010]
Applications Tested/Suitable for anti-PEG10 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-PEG10 antibody
WB: 1:1000

Western Blot (WB) of anti-PEG10 antibody
Western blot detection of PEG10 in Hela cell lysates using PEG10 mouse mAb (1:1000 diluted).Predicted band size:55KDa.Observed band size:55KDa, 95KDa.
anti-PEG10 antibody Western Blot (WB) (WB) image
Immunoprecipitation (IP) of anti-PEG10 antibody
Immunoprecipitation analysis of Hela cell lysates using PEG10 mouse mAb.
anti-PEG10 antibody Immunoprecipitation (IP) (IP) image
NCBI/Uniprot data below describe general gene information for PEG10. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55
NCBI Official Full Name
retrotransposon-derived protein PEG10 isoform 2
NCBI Official Synonym Full Names
paternally expressed 10
NCBI Official Symbol
PEG10  [Similar Products]
NCBI Official Synonym Symbols
EDR; HB-1; Mar2; MEF3L; Mart2; RGAG3
  [Similar Products]
NCBI Protein Information
retrotransposon-derived protein PEG10
UniProt Protein Name
Retrotransposon-derived protein PEG10
UniProt Synonym Protein Names
Embryonal carcinoma differentiation-regulated protein; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3-like protein 1; MEF3-like protein 1; Paternally expressed gene 10 protein; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; Ty3/Gypsy-like protein
UniProt Gene Name
PEG10  [Similar Products]
UniProt Synonym Gene Names
EDR; KIAA1051; MAR2; MART2; MEF3L1; RGAG3; MEF3-like protein 1  [Similar Products]
NCBI Summary for PEG10
This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. [provided by RefSeq, Oct 2014]
UniProt Comments for PEG10
PEG10: Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter. Up-regulated by MYC and dihydrotestosteron (DHT). Interacts with ALK1, SIAH1 and SIAH2. 2 isoforms of the human protein are produced by ribosomal frameshifting.

Protein type: Apoptosis; Cell cycle regulation; Cell development/differentiation; RNA-binding

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: negative regulation of transforming growth factor beta receptor signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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