AAB61574
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
podocalyxin isoform 1
NCBI Official Synonym Full Names
podocalyxin-like
NCBI Protein Information
podocalyxin; GCTM-2 antigen; podocalyxin-like protein 1
UniProt Protein Name
Podocalyxin
UniProt Synonym Protein Names
GCTM-2 antigen; Gp200; Podocalyxin-like protein 1
UniProt Synonym Gene Names
UniProt Entry Name
PODXL_HUMAN
NCBI Summary for PODXL
This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq, Jul 2008]
UniProt Comments for PODXL
PODXL: Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell- cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR- dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. Belongs to the podocalyxin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion
Chromosomal Location of Human Ortholog: 7q32-q33
Cellular Component: ruffle; extracellular space; microvillus membrane; integral to plasma membrane; lamellipodium; apical plasma membrane; cytoplasm; plasma membrane; lipid raft; filopodium
Molecular Function: protein binding
Biological Process: cell migration; negative regulation of cell adhesion; negative regulation of cell-cell adhesion; cell adhesion; leukocyte migration; positive regulation of cell-cell adhesion mediated by integrin; positive regulation of cell migration; regulation of microvillus biogenesis
Research Articles on PODXL
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Products associated with anti-PODXL antibody
Diseases associated with anti-PODXL antibody
Organs/Tissues associated with anti-PODXL antibody
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