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anti-TGM2 antibody :: Mouse Protein-glutamine gamma-glutamyltransferase 2 Monoclonal Antibody

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Catalog # MBS1493349
Unit / Price
  0.05 mg  /  $185 +1 FREE 8GB USB
  0.1 mg  /  $265 +1 FREE 8GB USB
Product Name

Protein-glutamine gamma-glutamyltransferase 2 (TGM2), Monoclonal Antibody

Popular Item
Full Product Name

Mouse anti Human Protein-glutamine gamma-glutamyltransferase 2(TGM2) monoclonal Antibody

Product Synonym Names
Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
190196
3D Structure
ModBase 3D Structure for P21980
Clonality
Monoclonal
Host
Mouse
Species Reactivity
Human. Other species are not tested. Please decide the specificity by homology
Specificity
Specific for TGM2 native and denatured forms
Purity/Purification
>95%, Protein G Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Non-conjugated
Immunogen
Recombinant Human Protein-glutamine gamma-glutamyltransferase 2(TGM2)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-48370 / sc-48387 / sc-73612
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-TGM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TGM2 antibody
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
Applications Tested/Suitable for anti-TGM2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-TGM2 antibody
Immunohistochemical of paraffin-embedded Human placenta tissue using MBS1493349 at dilution of 1:200.
anti-TGM2 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-TGM2 antibody
Immunohistochemical of paraffin-embedded Human Breast tissue using MBS1493349 at dilution of 1:200.
anti-TGM2 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-TGM2 antibody
All lanes: Mouse anti-TGM2 Monoclonal antibody at 1ug/ml
Lane 1: A549 whole cell lysate
Secondary Goat polyclonal to Mouse IgG at 1/5000 dilution
Predicted band size:77kd
Observed band size:77,62,39KD
Additional bands at:30kd

anti-TGM2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for TGM2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,671 Da
NCBI Official Full Name
protein-glutamine gamma-glutamyltransferase 2 isoform a
NCBI Official Synonym Full Names
transglutaminase 2
NCBI Official Symbol
NCBI Official Synonym Symbols
TG2; TGC; GNAH; HEL-S-45; G-ALPHA-h
  [Similar Products]
NCBI Protein Information
protein-glutamine gamma-glutamyltransferase 2
UniProt Protein Name
Protein-glutamine gamma-glutamyltransferase 2
UniProt Synonym Protein Names
Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2; TGase-2
UniProt Gene Name
UniProt Synonym Gene Names
TG(C); TGC; TGase C; TGase H; TGase-2  [Similar Products]
UniProt Entry Name
TGM2_HUMAN
NCBI Summary for TGM2
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for TGM2
TGM2: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. . Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation. Three alternatively spliced isoforms have been described.

Protein type: EC 2.3.2.13; Transferase

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: cytosol; endoplasmic reticulum; focal adhesion; intrinsic to plasma membrane; mitochondrion

Molecular Function: metal ion binding; protein binding; protein-glutamine gamma-glutamyltransferase activity

Biological Process: apoptotic cell clearance; elevation of mitochondrial calcium ion concentration; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); peptide cross-linking; positive regulation of apoptosis; positive regulation of cell adhesion; reduction of endoplasmic reticulum calcium ion concentration
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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