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anti-PSAP antibody :: Mouse anti-Human PSAP Monoclonal Antibody

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Catalog # MBS370103
Unit / Price
  5 Control Slides  /  $130 +1 FREE 8GB USB
  0.1 mL (Concentrate)  /  $165 +1 FREE 8GB USB
  3 ml (Prediluted)  /  $165 +1 FREE 8GB USB
  7 ml (Prediluted)  /  $210 +1 FREE 8GB USB
  0.5 mL (Concentrate)  /  $240 +1 FREE 8GB USB
  15 ml (Prediluted)  /  $325 +1 FREE 8GB USB
  1 mL (Concentrate)  /  $360 +1 FREE 8GB USB
Product Name

PSAP, Monoclonal Antibody

Also Known As

PSAP

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 10; NC_000010.10 (73576055..73611082, complement). Location: 10q21-q22
OMIM
176801
3D Structure
ModBase 3D Structure for P07602
Clonality
Monoclonal
Isotype
IgG1
Clone Number
PASE/4LJ
Host
Mouse
Species Reactivity
Human
Form/Format
PSAP is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Control
Prostate
Localization
Cytoplasmic
Reactivity Note
Paraffin, Frozen
Preparation and Storage
Store at 2 to 8 degree C in the dark.
ISO Certification
Manufactured in an ISO 13485:2016 Certified Laboratory.
Other Notes
Small volumes of anti-PSAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PSAP antibody
Prostatic specific acid phosphatase (PSAP) is an enzyme produced by the prostate. It may be found in increased amounts in men who have prostate cancer or other diseases. The highest levels of acid phosphatase are found in metastasized prostate cancer. Diseases of the bone, such as Paget's disease or hyperparathyroidism, diseases of blood cells, (such as Sickle-Cell Disease), Multiple Myeloma or Lysosomal Storage Diseases, (such as Gaucher's disease), will show moderately increased levels. Certain medications can cause temporary increases or decreases in acid phosphatase levels. Manipulation of the prostate gland through massage, biopsy or rectal exam before a test may increase the levels of PSAP. This antibody reacts with prostatic specific acid phosphatase in the glandular epithelium of the normal and Hyperplastic Prostate, Carcinoma of the prostate and metastatic cells of Prostatic Carcinoma. This marker may be helpful in pinpointing the site of origin in cases of Metastatic Carcinoma of the prostate, and is considered a more sensitive marker than PSA. However, it also offers less specificity.

Dilution Information of anti-PSAP antibody
anti-PSAP antibody Dilution Information image
Immunohistochemistry (IHC) of anti-PSAP antibody
anti-PSAP antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PSAP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
58,113 Da
NCBI Official Full Name
PSAP
NCBI Official Synonym Full Names
prosaposin
NCBI Official Symbol
NCBI Official Synonym Symbols
GLBA; SAP1; FLJ00245; MGC110993
  [Similar Products]
NCBI Protein Information
proactivator polypeptide; OTTHUMP00000019776; OTTHUMP00000019777; sphingolipid activator protein-1
UniProt Protein Name
Proactivator polypeptide
UniProt Synonym Protein Names
Protein ASaposin-B-ValSaposin-B; Alternative name(s):; Cerebroside sulfate activator; CSAct; Dispersin; Sphingolipid activator protein 1; SAP-1; Sulfatide/GM1 activatorSaposin-C; Alternative name(s):; A1 activator; Co-beta-glucosidase; Glucosylceramidase activator; Sphingolipid activator protein 2; SAP-2Saposin-D; Alternative name(s):; Component C; Protein C
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
GLBA; SAP1  [Similar Products]
UniProt Entry Name
SAP_HUMAN
NCBI Summary for PSAP
This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
UniProt Comments for PSAP
Function: The lysosomal degradation of sphingolipids takes place by the sequential action of specific hydrolases. Some of these enzymes require specific low-molecular mass, non-enzymic proteins: the sphingolipids activator proteins (coproteins).Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).

Subunit structure: Saposin-B is a homodimer.

Subcellular location: Lysosome.

Post-translational modification: This precursor is proteolytically processed to 4 small peptides, which are similar to each other and are sphingolipid hydrolase activator proteins.N-linked glycans show a high degree of microheterogeneity.The one residue extended Saposin-B-Val is only found in 5% of the chains.

Involvement in disease: Defects in PSAP are the cause of combined saposin deficiency (CSAPD) [

MIM:611721]; also known as prosaposin deficiency. CSAPD is due to absence of all saposins, leading to a fatal storage disorder with hepatosplenomegaly and severe neurological involvement. Ref.31 Ref.35Defects in PSAP saposin-B region are the cause of leukodystrophy metachromatic due to saposin-B deficiency (MLD-SAPB) [

MIM:249900]. MLD-SAPB is an atypical form of metachromatic leukodystrophy. It is characterized by tissue accumulation of cerebroside-3-sulfate, demyelination, periventricular white matter abnormalities, peripheral neuropathy. Additional neurological features include dysarthria, ataxic gait, psychomotr regression, seizures, cognitive decline and spastic quadriparesis.Defects in PSAP saposin-C region are the cause of atypical Gaucher disease (AGD) [

MIM:610539]. Affected individuals have marked glucosylceramide accumulation in the spleen without having a deficiency of glucosylceramide-beta glucosidase characteristic of classic Gaucher disease, a lysosomal storage disorder. Ref.32 Ref.37Defects in PSAP saposin-A region are the cause of atypical Krabbe disease (AKRD) [

MIM:611722]. AKRD is a disorder of galactosylceramide metabolism. AKRD features include progressive encephalopathy and abnormal myelination in the cerebral white matter resembling Krabbe disease. Ref.36Note=Defects in PSAP saposin-D region are found in a variant of Tay-Sachs disease (GM2-gangliosidosis).

Miscellaneous: Saposin-B co-purifies with 1 molecule of phosphatidylethanolamine.

Sequence similarities: Contains 2 saposin A-type domains.Contains 4 saposin B-type domains.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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