NP_004160.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,672 Da
NCBI Official Full Name
serine hydroxymethyltransferase, cytosolic isoform 1
NCBI Official Synonym Full Names
serine hydroxymethyltransferase 1 (soluble)
NCBI Official Synonym Symbols
NCBI Protein Information
serine hydroxymethyltransferase, cytosolic; serine methylase; glycine hydroxymethyltransferase; cytoplasmic serine hydroxymethyltransferase
UniProt Protein Name
Serine hydroxymethyltransferase, cytosolic
UniProt Synonym Protein Names
Glycine hydroxymethyltransferase; Serine methylase
UniProt Synonym Gene Names
UniProt Entry Name
GLYC_HUMAN
NCBI Summary for SHMT
This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
UniProt Comments for SHMT
SHMT1: Interconversion of serine and glycine. Belongs to the SHMT family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; Mitochondrial; Cofactor and Vitamin Metabolism - one carbon pool by folate; Methyltransferase; EC 2.1.2.1; Lyase; Other Amino Acids Metabolism - cyanoamino acid; Energy Metabolism - methane
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus; cytosol
Molecular Function: L-allo-threonine aldolase activity; amino acid binding; protein homodimerization activity; glycine hydroxymethyltransferase activity; pyridoxal phosphate binding
Biological Process: purine base biosynthetic process; vitamin metabolic process; folic acid metabolic process; L-serine catabolic process; glycine biosynthetic process from serine; protein tetramerization; water-soluble vitamin metabolic process; carnitine biosynthetic process; protein homotetramerization
Research Articles on SHMT
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Products associated with anti-SHMT antibody
Pathways associated with anti-SHMT antibody
Diseases associated with anti-SHMT antibody
Organs/Tissues associated with anti-SHMT antibody
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