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anti-SSTR5 antibody :: Mouse anti-Human Somatostatin Receptor Type 5 Monoclonal Antibody

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Catalog # MBS600663
Unit / Price
  0.1 mg  /  $630 +1 FREE 8GB USB
anti-SSTR5 antibody
Product Name

Somatostatin Receptor Type 5 (SSTR5), Monoclonal Antibody

Popular Item
Also Known As

Somatostatin Receptor Type 5 (Somatostatin Receptor 5, Somatostatin Receptor Subtype 5, SS5R, SSTr5)

Product Synonym Names
Anti -Somatostatin Receptor Type 5 (Somatostatin Receptor 5, Somatostatin Receptor Subtype 5, SS5R, SSTr5)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 16; NC_000016.9 (1122756..1131454). Location: 16p13.3
OMIM
182455
3D Structure
ModBase 3D Structure for P35346
Clonality
Monoclonal
Isotype
IgG1
Clone Number
8B45
Host
Mouse
Species Reactivity
Human
Specificity
Recognizes human SSTR5. Stains SSTR5 transfectants but not irrelevant transfectants. Species Sequence Homology: mouse (65%), rat (68%)
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.
Immunogen
NS0 cells transfected with human Somatostatin Receptor Type 5 (P35346).
Preparation and Storage
-20 degree C
Other Notes
Small volumes of anti-SSTR5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SSTR5 antibody
Somatostatin Receptor type 5 (SSTR5) is one of five 7-transmembrane G-protein-coupled receptors for somatostatins 14 and 28. Within the extracellular portions, human SSTR5 shares 65% and 68% aa identity with mouse and rat SSTR5, respectively. It is expressed in adult pituitary, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus. It is an inhibitory receptor that transduces the antiproliferative and antisecretive effects of somatostatins.
Product Categories/Family for anti-SSTR5 antibody
Applications Tested/Suitable for anti-SSTR5 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-SSTR5 antibody
Dilution: Flow Cytometry: 25ug/ml; 10ul labels 1-5 x 10e5 MCF-7 cells in a total reaction volume 200ul. For intracellular staining, cells must first be fixed and permeabilized using 4% paraformaldehyde and 0.1% saponin in PBS.

Storage and Stability:
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
NCBI/Uniprot data below describe general gene information for SSTR5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,202 Da[Similar Products]
NCBI Official Full Name
somatostatin receptor type 5
NCBI Official Synonym Full Names
somatostatin receptor 5
NCBI Official Symbol
SSTR5  [Similar Products]
NCBI Official Synonym Symbols
SS-5-R
  [Similar Products]
NCBI Protein Information
somatostatin receptor type 5; OTTHUMP00000158593; somatostatin receptor subtype 5
UniProt Protein Name
Somatostatin receptor type 5
Protein Family
UniProt Gene Name
SSTR5  [Similar Products]
UniProt Entry Name
SSR5_HUMAN
NCBI Summary for SSTR5
Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.
UniProt Comments for SSTR5
SSTR5: Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Cell cycle regulation

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: neuron projection; integral to plasma membrane; plasma membrane

Molecular Function: neuropeptide binding; somatostatin receptor activity

Biological Process: positive regulation of cytokinesis; G-protein coupled receptor protein signaling pathway; negative regulation of cell proliferation; synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; neuropeptide signaling pathway; glucose homeostasis; regulation of insulin secretion

Disease: Pituitary Adenoma, Growth Hormone-secreting
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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