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anti-SOX12 antibody :: Mouse anti-Human SOX12 Monoclonal Antibody

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Catalog # MBS120310
Unit / Price
  0.1 mg  /  $345 +1 FREE 8GB USB
Product Name

SOX12, Monoclonal Antibody

Also Known As

Mouse monoclonal antibody Anti-Human SOX12

Product Synonym Names
Homo sapiens SRY (sex determining region Y)-box 12; SOX22
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
2909
OMIM
601947
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
86C2a
Host
Mouse
Species Reactivity
Human
Concentration
100 ug/ml (1.0 ml) (lot specific)
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Other Notes
Small volumes of anti-SOX12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SOX12 antibody
Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [NCBI Entrez Gene Summary]
Applications Tested/Suitable for anti-SOX12 antibody
Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB)

Quality Control of anti-SOX12 antibody
Western blot analysis of immunized recombinant protein, using anti-SOX12 monoclonal antibody.
anti-SOX12 antibody Quality Control image
Quality Control #2 of anti-SOX12 antibody
Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-SOX12 antibody Quality Control #2 image
Western Blot (WB) of anti-SOX12 antibody
Detection of human SOX12 by Western blot.

Samples: Whole cell lysate (25 ug) from HT-1080 cells. [Lot No. 86C2a-1]

Predicted molecular weight: 34 kDa
anti-SOX12 antibody Western Blot (WB) (WB) image
Immunocytochemistry (ICC) of anti-SOX12 antibody
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-SOX12 mAb. [Lot No. 86C2a-1]
anti-SOX12 antibody Immunocytochemistry (ICC) (ICC) image
NCBI/Uniprot data below describe general gene information for SOX12. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,122 Da
NCBI Official Full Name
Homo sapiens SRY (sex determining region Y)-box 12, mRNA
NCBI Official Synonym Full Names
SRY (sex determining region Y)-box 12
NCBI Official Symbol
SOX12  [Similar Products]
NCBI Official Synonym Symbols
SOX22
  [Similar Products]
NCBI Protein Information
transcription factor SOX-12; SOX-22 protein; SRY-related HMG-box gene 22
UniProt Protein Name
Transcription factor SOX-12
UniProt Synonym Protein Names
Protein SOX-22
Protein Family
UniProt Gene Name
SOX12  [Similar Products]
UniProt Entry Name
SOX12_HUMAN
NCBI Summary for SOX12
Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [provided by RefSeq, Jan 2013]
UniProt Comments for SOX12
SOX12: Binds to the sequence 5'-AACAAT-3'.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: nucleus

Molecular Function: DNA binding

Biological Process: regulation of transcription from RNA polymerase II promoter; cell fate commitment; transcription, DNA-dependent; spinal cord development; positive regulation of transcription from RNA polymerase II promoter; protein-DNA complex assembly
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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