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anti-SOX4 antibody :: Mouse anti-Human SOX4 Monoclonal Antibody

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Catalog # MBS120428
Unit / Price
  0.1 mg  /  $345 +1 FREE 8GB USB
Product Name

SOX4, Monoclonal Antibody

Popular Item
Also Known As

Mouse monoclonal antibody Anti-Human SOX4

Product Synonym Names
Homo sapiens SRY (sex determining region Y)-box 4 (SOX4), mRNA.; EVI16
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
4912
OMIM
184430
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
154C4a
Host
Mouse
Species Reactivity
Human
Concentration
100 ug/ml (1.0 ml) (lot specific)
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Other Notes
Small volumes of anti-SOX4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SOX4 antibody
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.[NCBI Entrez Gene Summary
Applications Tested/Suitable for anti-SOX4 antibody
Dot Blot (DB), Immunocytochemistry (ICC)

Quality Control of anti-SOX4 antibody
Western blot analysis of immunized recombinant protein, using anti-SOX4 monoclonal antibody.
anti-SOX4 antibody Quality Control image
Quality Control #2 of anti-SOX4 antibody
Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-SOX4 antibody Quality Control #2 image
Immunocytochemistry (ICC) of anti-SOX4 antibody
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-SOX4 mAb. [Lot No.154C4a-2]
anti-SOX4 antibody Immunocytochemistry (ICC) (ICC) image
NCBI/Uniprot data below describe general gene information for SOX4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Related Accession #
Molecular Weight
47,263 Da
NCBI Official Full Name
Homo sapiens SRY (sex determining region Y)-box 4 (SOX4), mRNA
NCBI Official Synonym Full Names
SRY (sex determining region Y)-box 4
NCBI Official Symbol
NCBI Official Synonym Symbols
EVI16
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NCBI Protein Information
transcription factor SOX-4; SRY-related HMG-box gene 4; ecotropic viral integration site 16
UniProt Protein Name
Transcription factor SOX-4
Protein Family
UniProt Gene Name
UniProt Entry Name
SOX4_HUMAN
NCBI Summary for SOX4
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008]
UniProt Comments for SOX4
SOX4: Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus

Molecular Function: protein binding; protein heterodimerization activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; negative regulation of protein export from nucleus; positive regulation of translation; positive regulation of apoptosis; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; heart development; regulation of protein stability; Wnt receptor signaling pathway through beta-catenin; glucose homeostasis; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; glial cell proliferation; negative regulation of cell proliferation; sympathetic nervous system development; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; skeletal development; positive regulation of Wnt receptor signaling pathway; T cell differentiation; glial cell development; pro-B cell differentiation; protein stabilization; positive regulation of insulin secretion; DNA damage response, detection of DNA damage; spinal cord motor neuron differentiation; endocrine pancreas development; limb bud formation; spinal cord development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein ubiquitination; neural tube formation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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