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anti-SOX9 antibody :: Mouse SOX9/SRY-box 9 Monoclonal Antibody

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Catalog # MBS4380489
Unit / Price
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  0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
  0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $340 +1 FREE 8GB USB
  0.1 mg (Without BSA & Azide at 1mg/ml)  /  $340 +1 FREE 8GB USB
Product Name

SOX9/SRY-box 9, Monoclonal Antibody

Popular Item
Full Product Name

SOX9/SRY-box 9

Product Synonym Names
Campomelic Dysplasia Autosomal Sex Reversal (CMD1); SRA1; SRXX2; SRY (sex determining region Y) box 9; SRY related HMG box gene 9; Transcription factor SOX9
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P48436
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
PCRP-SOX9-1A2
Host
Mouse
Species Reactivity
Human. Others not tested.
Specificity
The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19, 000, full-length human proteins. Sox genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. SOX9 plays an important role in the normal skeletal development. It may regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Immunogen
Recombinant full-length human SOX9 protein
Cellular Localization
Nuclear
Hu-chromosome Location
17q24.3
Positive Control
HepG2 Cells. Pancreas
Other Notes
Small volumes of anti-SOX9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SOX9 antibody
Immunohistochemistry (IHC) Formalin
Application Notes for anti-SOX9 antibody
IHC-F: 2-4ug/ml for 30 min at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.

Immunohistochemistry (IHC) of anti-SOX9 antibody
Formalin-fixed, paraffin-embedded human Pancreas stained with SOX9 Mouse Monoclonal Antibody (PCRP-SOX9-1A2).
anti-SOX9 antibody Immunohistochemistry (IHC) (IHC) image
SDS-Page of anti-SOX9 antibody
SDS-PAGE Analysis Purified SOX9 Mouse Monoclonal Antibody (PCRP-SOX9-1A2).Confirmation of Integrity and Purity of Antibody.
anti-SOX9 antibody SDS-Page image
Testing Data of anti-SOX9 antibody
Analysis of Protein Array containing more than 19, 000 full-length human proteins using SOX9 Mouse Monoclonal Antibody (PCRP-SOX9-1A2) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
anti-SOX9 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for SOX9. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
65kDa
NCBI Official Full Name
transcription factor SOX-9
NCBI Official Synonym Full Names
SRY-box 9
NCBI Official Symbol
NCBI Official Synonym Symbols
CMD1; SRA1; CMPD1; SRXX2; SRXY10
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NCBI Protein Information
transcription factor SOX-9
UniProt Protein Name
Transcription factor SOX-9
Protein Family
UniProt Gene Name
NCBI Summary for SOX9
The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. [provided by RefSeq, Jul 2008]
UniProt Comments for SOX9
Transcriptional regulator (PubMed:24038782). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219 (). Plays a role in chondrocyte differentiation (). Important for normal skeletal development (PubMed:24038782).
Product References and Citations for anti-SOX9 antibody
Zhu, H., et al. 2013. Upregulation of SOX9 in osteosarcoma and its association with tumor progression and patients prognosis. Diagn.Pathol. 8:183.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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