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anti-CCT2 antibody :: Rat anti-Human T-complex Protein 1 beta Monoclonal Antibody

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Catalog # MBS608559
Unit / Price
  0.1 mg  /  $745 +1 FREE 8GB USB
anti-CCT2 antibody
Product Name

T-complex Protein 1 beta (CCT2), Monoclonal Antibody

Also Known As

T-complex Protein 1 beta (T-complex Protein 1 beta Subunit, TCP1 beta, TCP-1 beta, 99D8.1, Chaperonin Containing T-complex Polypeptide 1 beta Subunit, CCT beta, CCT-beta, CCTB, Chaperonin Containing TCP1 Subunit 2 (beta), CCT2, MGC142074, MGC142076, PRO16

Product Synonym Names
Anti -T-complex Protein 1 beta (T-complex Protein 1 beta Subunit, TCP1 beta, TCP-1 beta, 99D8.1, Chaperonin Containing T-complex Polypeptide 1 beta Subunit, CCT beta, CCT-beta, CCTB, Chaperonin Containing TCP1 Subunit 2 (beta), CCT2, MGC142074, MGC142076, PRO16
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 12; NC_000012.11 (69979208..69995357). Location: 12q15
OMIM
605139
3D Structure
ModBase 3D Structure for P78371
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
10B485
Host
Rat
Species Reactivity
Human
Specificity
Recognizes the beta polypeptide of the human chaperonin molecule complex at ~60kD. Species Crossreactivity: Rat, Bovine, Chicken, Sheep, Mouse, Dog, Rabbit, Hamster, Pig, Monkey.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Immunogen
Human CCT beta.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-CCT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CCT2 antibody
The intact CCT complex is composed of eight polypeptides in a double-ring structure. CCT is important within cells in aiding the folding of proteins including actin, tubulin and the VHL tumor suppressor protein.
Applications Tested/Suitable for anti-CCT2 antibody
Western Blot (WB)
Application Notes for anti-CCT2 antibody
Suitable for use in Western Blot.
Dilution: Western Blot: 1:100-1:500
NCBI/Uniprot data below describe general gene information for CCT2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,488 Da[Similar Products]
NCBI Official Full Name
T-complex protein 1 subunit beta isoform 1
NCBI Official Synonym Full Names
chaperonin containing TCP1, subunit 2 (beta)
NCBI Official Symbol
NCBI Official Synonym Symbols
CCTB; 99D8.1; PRO1633; CCT-beta; MGC142074; MGC142076; TCP-1-beta
  [Similar Products]
NCBI Protein Information
T-complex protein 1 subunit beta; T-complex protein 1, beta subunit; chaperonin containing t-complex polypeptide 1, subunit 2; chaperonin containing t-complex polypeptide 1, beta subunit
UniProt Protein Name
T-complex protein 1 subunit beta
UniProt Synonym Protein Names
CCT-beta
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
99D8.1; CCTB  [Similar Products]
UniProt Entry Name
TCPB_HUMAN
NCBI Summary for CCT2
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
UniProt Comments for CCT2
CCT-beta: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Belongs to the TCP-1 chaperonin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Chaperone

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: chaperonin-containing T-complex; microtubule; cytoplasm; cytosol

Molecular Function: protein binding; ubiquitin protein ligase binding; unfolded protein binding; ATP binding

Biological Process: 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; binding of sperm to zona pellucida; chaperone-mediated protein complex assembly
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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