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anti-TLR7 antibody :: Mouse anti-Human TLR7 Monoclonal Antibody

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Catalog # MBS200017
Unit / Price
  0.05 mL  /  $240 +1 FREE 8GB USB
  0.1 mL  /  $315 +1 FREE 8GB USB
Immunofluorescence (IF)
Product Name

TLR7, Monoclonal Antibody

Also Known As

TLR7 antibody

Product Synonym Names
toll-like receptor 7; PRO285; UNQ248; tlr 7
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1049
OMIM
AF240467 mRNA
3D Structure
ModBase 3D Structure for Q9NYK1
Clonality
Monoclonal
Isotype
IgG1, k
Clone Number
4F4
Host
Mouse
Species Reactivity
Human
Purity/Purification
By protein-G affinity chromatography
Form/Format
Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
Concentration
1mg/ml (lot specific)
Antigen Species
Human
Immunogen
Recombinant human TLR7 (451-500aa) purified from E. coli
Clone Note
Anti-human TLR7 mAb, clone 4F4, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human TLR7 protein.
Preparation and Storage
Can be stored at 4 degree C.
For long term storage, aliquot and store at -20 degree C.
Avoid repeated freezing and thawing cycles.
Other Notes
Small volumes of anti-TLR7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TLR7 antibody
TLR7 is one of toll-like receptors which are type I transmembrane proteins involved in innate immunity by recognizing microbial conserved structures. These proteins are characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain, and act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Human TLR7 (hTLR7) is predominantly expressed in lung, placenta and spleen and hTLR7,8 genes are located on the sex chromosome X. hTLR7 may play an important role in detecting and combating viral infections.
Product Categories/Family for anti-TLR7 antibody
Applications Tested/Suitable for anti-TLR7 antibody
ELISA (EIA), Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-TLR7 antibody
WB: 1:500 ~ 2,000.
Recommended starting dilution is 1:1,000.

Immunofluorescence (IF) of anti-TLR7 antibody
ICC/IF analysis of TLR7 in THP-1 cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human TLR7 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).
anti-TLR7 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for TLR7. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
120,922 Da
NCBI Official Full Name
toll-like receptor 7
NCBI Official Synonym Full Names
toll like receptor 7
NCBI Official Symbol
NCBI Official Synonym Symbols
TLR7-like
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NCBI Protein Information
toll-like receptor 7
UniProt Protein Name
Toll-like receptor 7
Protein Family
UniProt Gene Name
NCBI Summary for TLR7
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008]
UniProt Comments for TLR7
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response ().
Product References and Citations for anti-TLR7 antibody
Lee J., et al. (2003) Proc. Natl. Acad. Sci. USA. 100, 6646-6651; Crozat K., et al. (2004) Proc. Natl. Acad. Sci. USA. 101, 6835-6836; Muzio M., et al. (1998) J. Exp. Med. 187, 2097-2101; Horng T., et al. (2002) Nature 420, 329-333

Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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