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anti-TFAP2C antibody :: Mouse anti-Human Transcription Factor AP-2 gamma Monoclonal Antibody

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Catalog # MBS603666
Unit / Price
  0.1 mg  /  $565 +1 FREE 8GB USB
anti-TFAP2C antibody
Product Name

Transcription Factor AP-2 gamma (TFAP2C), Monoclonal Antibody

Also Known As

Transcription Factor AP-2 gamma (TFAP2G, Activating Enhancer Binding Protein 2 gamma, AP2-gamma, hAP-2g, TFAP2C)

Product Synonym Names
Anti -Transcription Factor AP-2 gamma (TFAP2G, Activating Enhancer Binding Protein 2 gamma, AP2-gamma, hAP-2g, TFAP2C)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 20; NC_000020.10 (55204358..55214339). Location: 20q13.2
OMIM
601602
3D Structure
ModBase 3D Structure for Q92754
Clonality
Monoclonal
Isotype
IgG1
Clone Number
8C335
Host
Mouse
Species Reactivity
Human
Specificity
Recognizes human Transcription Factor AP-2 gamma.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.
Immunogen
Partial sequence of recombinant full-length protein to human Transcription Factor AP-2 gamma
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-TFAP2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TFAP2C antibody
Western Blot (WB), Gel Shift Assay (GS/EMSA)
Application Notes for anti-TFAP2C antibody
Suitable for use in Western Blot and Dot Blot.
NCBI/Uniprot data below describe general gene information for TFAP2C. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,177 Da[Similar Products]
NCBI Official Full Name
transcription factor AP-2 gamma
NCBI Official Synonym Full Names
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
NCBI Official Symbol
TFAP2C  [Similar Products]
NCBI Official Synonym Symbols
ERF1; TFAP2G; hAP-2g; AP2-GAMMA
  [Similar Products]
NCBI Protein Information
transcription factor AP-2 gamma; OTTHUMP00000031355; estrogen receptor factor 1; transcription factor ERF-1; activating enhancer-binding protein 2 gamma; transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma)
UniProt Protein Name
Transcription factor AP-2 gamma
UniProt Synonym Protein Names
Activating enhancer-binding protein 2 gamma; Transcription factor ERF-1
Protein Family
UniProt Gene Name
TFAP2C  [Similar Products]
UniProt Entry Name
AP2C_HUMAN
NCBI Summary for TFAP2C
The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq]
UniProt Comments for TFAP2C
AP-2 gamma: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. During retinoic acid-mediated differentiation. Belongs to the AP-2 family.

Protein type: DNA-binding; Transcription factor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: nucleus

Molecular Function: protein dimerization activity; protein binding; DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; somatic stem cell maintenance; male gonad development; sebaceous gland development; germ-line stem cell maintenance; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic; trophectodermal cell differentiation; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; hair follicle development; cell-cell signaling; positive regulation of transcription from RNA polymerase II promoter; forebrain neuron fate commitment; cerebral cortex development; regulation of epidermis development
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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