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anti-TNNI3 antibody :: Mouse anti-Human Troponin I Monoclonal Antibody

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Catalog # MBS530548
Unit / Price
  1 mg  /  $520 +1 FREE 8GB USB
anti-TNNI3 antibody
Product Name

Troponin I (TNNI3), Monoclonal Antibody

Popular Item
Full Product Name

Troponin I antibody (Cardiac)

Product Synonym Names
Monoclonal Troponin I (Cardiac); Anti-Troponin I (Cardiac)
Matching Pairs
Capture Antibody: Troponin I Clone #M9011521 (MBS530548)
Detection Antibody: Troponin I Clone #M805142 (MBS530749)
Comments: Quantitative sandwich immunoassay
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
115210
3D Structure
ModBase 3D Structure for P19429
Clonality
Monoclonal
Isotype
IgG1
Clone Number
M9011521
Host
Mouse
Species Reactivity
Human
Purity/Purification
Troponin I antibody (Cardiac) was purified by chromatography on protein A Sepharose.
Form/Format
Protein A purified IgG supplied in PBS, pH 7.4, 0.1 % NaN3.
Biological Significance
Human troponin I is presented in cardiac muscle tissue by a single isoform with molecular weight 23876 Da and it consists of 209 amino acid residues. cTnI molecule contains two serines in the 22 and 23 positions. Both amino acid residues can be phosphorylated in vivo by protein kinase A, so four forms of protein ? one dephospho, two monophospho and one bisphospho ? can coexist in the cell.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Immunogen
Troponin I antibody (cardiac) was raised in mouse using amino acid residues 83-93 of cTnI as the immunogen.
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of anti-TNNI3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TNNI3 antibody
Mouse monoclonal Troponin I antibody (Cardiac)
Product Categories/Family for anti-TNNI3 antibody
Applications Tested/Suitable for anti-TNNI3 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-TNNI3 antibody
Use as the coating antibody with either MBS530749 or 10-7967 as the detection antibody
NCBI/Uniprot data below describe general gene information for TNNI3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
24,008 Da[Similar Products]
NCBI Official Full Name
troponin I, cardiac muscle
NCBI Official Synonym Full Names
troponin I type 3 (cardiac)
NCBI Official Symbol
TNNI3  [Similar Products]
NCBI Official Synonym Symbols
CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF
  [Similar Products]
NCBI Protein Information
troponin I, cardiac muscle
UniProt Protein Name
Troponin I, cardiac muscle
UniProt Synonym Protein Names
Cardiac troponin I
Protein Family
UniProt Gene Name
TNNI3  [Similar Products]
UniProt Synonym Gene Names
TNNC1  [Similar Products]
UniProt Entry Name
TNNI3_HUMAN
NCBI Summary for TNNI3
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]
UniProt Comments for TNNI3
TNNI3: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1. Belongs to the troponin I family.

Protein type: Motor; Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: sarcomere; troponin complex; cytosol

Molecular Function: troponin T binding; protein domain specific binding; troponin C binding; protein binding; metal ion binding; calcium channel inhibitor activity; actin binding; calcium-dependent protein binding; protein kinase binding

Biological Process: cellular calcium ion homeostasis; regulation of smooth muscle contraction; heart contraction; regulation of systemic arterial blood pressure by ischemic conditions; heart development; ventricular cardiac muscle morphogenesis; vasculogenesis; negative regulation of ATPase activity; cardiac muscle contraction; muscle filament sliding

Disease: Cardiomyopathy, Dilated, 1ff; Cardiomyopathy, Familial Restrictive, 1; Cardiomyopathy, Familial Hypertrophic, 7; Cardiomyopathy, Dilated, 2a
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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