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anti-Tnnt2 antibody :: Mouse Troponin T Monoclonal Antibody

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Catalog # MBS530117
Unit / Price
  1 mg  /  $485 +1 FREE 8GB USB
anti-Tnnt2 antibody
Product Name

Troponin T (Tnnt2), Monoclonal Antibody

Popular Item
Also Known As

Troponin T antibody (Cardiac)

Product Synonym Names
Monoclonal Troponin T (Cardiac); Anti-Troponin T (Cardiac)
Matching Pairs
Antibody: Troponin T Clone #M401134 (MBS530117)
Antigen: Troponin T (MBS537207)
Comments: >98% pure by SDS-PAGE
Matching Pairs
Capture Antibody: Troponin T Clone #M322512 (MBS531260)
Detection Antibody: Troponin T Clone #M401134 (MBS530117)
Comments: Quantitative sandwich immunoassay
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
289
3D Structure
ModBase 3D Structure for P50753
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
M401134
Host
Mouse
Species Reactivity
Human cardiac Troponin T 100%
Human skeletal Tropinin T 0%
Purity/Purification
Troponin T antibody (Cardiac) was purified by chromatography on protein A Sepharose.
Form/Format
Purified IgG in PBS buffer, pH 7.4, 0.09% NaN3
Concentration
5.8 mg/mL (lot specific)
Immunogen
Human Cardiac Troponin T
Affinity Constant
Not tested
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Biological Significance
Troponin T is a part of the troponin complex. It binds to tropomyosin, interlocking them to form a troponin-tropomyosin complex. Troponin T binds to tropomyosin and helps position it on actin. It also modulates contraction of striated muscle. The tissue specific subtypes are slow skeletal troponin T1, cardiac troponin T2, and fast skeletal troponin T3.
Preparation and Storage
Store at 4°C for short term, -20°C for longer storage.
Other Notes
Small volumes of anti-Tnnt2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Tnnt2 antibody
Mouse monoclonal Troponin T antibody (Cardiac)
Product Categories/Family for anti-Tnnt2 antibody
Applications Tested/Suitable for anti-Tnnt2 antibody
ELISA (EIA)
Application Notes for anti-Tnnt2 antibody
Suggested ELISA titer is 1:30,000.
NCBI/Uniprot data below describe general gene information for Tnnt2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
NCBI Official Full Name
troponin T
NCBI Official Synonym Full Names
troponin T type 2 (cardiac)
NCBI Official Symbol
Tnnt2  [Similar Products]
NCBI Official Synonym Symbols
Ctt; CTTG; Tnnt3; RATCTTG
  [Similar Products]
NCBI Protein Information
troponin T, cardiac muscle
UniProt Protein Name
Troponin T, cardiac muscle
UniProt Synonym Protein Names
Cardiac muscle troponin T; cTnT
Protein Family
UniProt Gene Name
Tnnt2  [Similar Products]
UniProt Synonym Gene Names
TnTc; cTnT  [Similar Products]
UniProt Entry Name
TNNT2_RAT
NCBI Summary for Tnnt2
tropomyosin-binding subunit of troponin; confers calcium-sensitivy to actinomysin ATPase activity in striated muscle [RGD, Feb 2006]
UniProt Comments for Tnnt2
TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Motor

Cellular Component: sarcomere; troponin complex; myofibril; cytoplasm; striated muscle thin filament

Molecular Function: protein binding, bridging; troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; actin binding; tropomyosin binding

Biological Process: actin crosslink formation; metabolic process; protein heterooligomerization; atrial cardiac muscle morphogenesis; regulation of muscle contraction; heart development; regulation of muscle filament sliding speed; sarcomere organization; regulation of heart contraction; muscle filament sliding; muscle contraction; positive regulation of ATPase activity; ventricular cardiac muscle morphogenesis; response to calcium ion; negative regulation of ATPase activity; cardiac muscle contraction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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