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anti-TUBB1 antibody :: Mouse anti-Human TUBB1 Monoclonal Antibody

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Catalog # MBS120480
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Product Name

TUBB1, Monoclonal Antibody

Full Product Name

Mouse monoclonal antibody Anti-Human TUBB1

Product Synonym Names
Homo sapiens tubulin, beta 1, mRNA (cDNA clone MGC:44928 IMAGE:5180793), complete cds.; dJ543J19.4
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
612901
Clonality
Monoclonal
Isotype
IgG1
Clone Number
600C2a
Host
Mouse
Species Reactivity
Human
Concentration
100 ug/ml (1.0 ml) (lot specific)
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Other Notes
Small volumes of anti-TUBB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TUBB1 antibody
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain By similarity.[UniProtKB Function]
Applications Tested/Suitable for anti-TUBB1 antibody
Dot Blot (DB), Immunocytochemistry (ICC)

Quality Control of anti-TUBB1 antibody
Western blot analysis of immunized recombinant protein, using anti-TUBB1 monoclonal antibody.
anti-TUBB1 antibody Quality Control image
Quality Control #2 of anti-TUBB1 antibody
Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-TUBB1 antibody Quality Control #2 image
Immunocytochemistry (ICC) of anti-TUBB1 antibody
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-TUBB1 mAb. [Lot No.600C2a-1]
anti-TUBB1 antibody Immunocytochemistry (ICC) (ICC) image
NCBI/Uniprot data below describe general gene information for TUBB1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Related Accession #
Molecular Weight
50,327 Da
NCBI Official Full Name
Homo sapiens tubulin, beta 1, mRNA
NCBI Official Synonym Full Names
tubulin, beta 1 class VI
NCBI Official Symbol
TUBB1  [Similar Products]
NCBI Protein Information
tubulin beta-1 chain; beta tubulin 1, class VI; class VI beta-tubulin
UniProt Protein Name
Tubulin beta-1 chain
Protein Family
UniProt Gene Name
TUBB1  [Similar Products]
UniProt Entry Name
TBB1_HUMAN
NCBI Summary for TUBB1
This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.[provided by RefSeq, Jul 2010]
UniProt Comments for TUBB1
TUBB1: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Interacts with RANBP10. Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins. Belongs to the tubulin family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20q13.32

Cellular Component: microtubule; cytoplasm

Molecular Function: GTPase activity; GTP binding; structural constituent of cytoskeleton

Biological Process: protein polymerization; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; spindle assembly; transmembrane transport

Disease: Macrothrombocytopenia, Autosomal Dominant, Tubb1-related
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-TUBB1 antibody
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