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anti-PLAU antibody :: anti-Human uPA, clone 3G65 Monoclonal Antibody

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Catalog # MBS135046
Unit / Price
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  1 mg  /  $510 +1 FREE 8GB USB
  10 mg  /  $3,680 +4 FREE 8GB USB
anti-PLAU antibody
Product Name

uPA, clone 3G65 (PLAU), Monoclonal Antibody

Popular Item
Full Product Name

Mouse monoclonal to human uPA, clone 3G65

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 10; NC_000010.10 (75670862..75677259). Location: 10q22.2
OMIM
191840
3D Structure
ModBase 3D Structure for P00749
Clonality
Monoclonal
Isotype
IgG
Clone Number
724-3G6-5
Host
Host: Mouse; Source: Hybridoma cell culture
Species Reactivity
Human
Purity/Purification
IgG fraction
Form/Format
Frozen liquid
Concentration
1.79 mg/ml (lot specific)
Aliquot
1 x 1.0mg
Volume
0.559ml
Immunogen
Recombinant full length wild-type human protein (Glycosylated).
Target Information
Recognises the beta chain of Urokinase (uPA)
Target Molecular Weight
54000
Buffer
0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6
Extinction Coefficient
1.36
Preparation and Storage
Store at -70 degree C. Shelf Life: 5 years from delivery
Other Notes
Small volumes of anti-PLAU antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PLAU antibody
Capture monoclonal antibody directed to the C-terminal beta (heavy) chain region of human uPA, which includes the active site. IgG fraction purified by immobilized Protein G. Isotype IgG.
Applications Tested/Suitable for anti-PLAU antibody
ELISA (EIA), Capture, Western Blot (WB)
NCBI/Uniprot data below describe general gene information for PLAU. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
160,000
NCBI Official Full Name
urokinase-type plasminogen activator isoform 2
NCBI Official Synonym Full Names
plasminogen activator, urokinase
NCBI Official Symbol
NCBI Official Synonym Symbols
ATF; QPD; UPA; URK; u-PA; BDPLT5
  [Similar Products]
NCBI Protein Information
urokinase-type plasminogen activator; U-plasminogen activator; plasminogen activator, urinary
UniProt Protein Name
Urokinase-type plasminogen activator
UniProt Gene Name
UniProt Synonym Gene Names
U-plasminogen activator; uPA  [Similar Products]
UniProt Entry Name
UROK_HUMAN
NCBI Summary for PLAU
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
UniProt Comments for PLAU
uPA: Specifically cleave the zymogen plasminogen to form the active enzyme plasmin. Defects in PLAU are the cause of Quebec platelet disorder (QPD). QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Protease; Secreted, signal peptide; EC 3.4.21.73; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q22.2

Cellular Component: extracellular space; cell surface; focal adhesion; extracellular region; plasma membrane

Molecular Function: protein binding; serine-type endopeptidase activity

Biological Process: regulation of cell adhesion mediated by integrin; fibrinolysis; regulation of smooth muscle cell migration; smooth muscle cell migration; response to hypoxia; regulation of receptor activity; chemotaxis; signal transduction; proteolysis; blood coagulation; regulation of cell proliferation

Disease: Quebec Platelet Disorder; Alzheimer Disease
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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