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anti-PLAUR antibody :: Mouse anti-Human Urokinase Plasminogen Activator Receptor Monoclonal Antibody

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Catalog # MBS604082
Unit / Price
  0.1 mL  /  $525 +1 FREE 8GB USB
anti-PLAUR antibody
Product Name

Urokinase Plasminogen Activator Receptor (PLAUR), Monoclonal Antibody

Also Known As

Urokinase Plasminogen Activator Receptor (uPAR, CD87)

Product Synonym Names
Anti -Urokinase Plasminogen Activator Receptor (uPAR, CD87)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 19; NC_000019.9 (44150248..44174502, complement). Location: 19q13
OMIM
173391
3D Structure
ModBase 3D Structure for Q03405
Clonality
Monoclonal
Isotype
IgG1
Clone Number
9B16
Host
Mouse
Species Reactivity
Human
Specificity
Recognizes human Urokinase Plasminogen Activator Receptor (uPAR). Reacts with an epitope on domain 1 of human uPAR that is different from that of U2610-03C. Does not crossreact with murine uPAR, human uPA, human tPA or human PAI-1.
Purity/Purification
Affinity Purified
Purified by Protein A/G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide.
Immunogen
Native human Urokinase Plasminogen Activator Receptor.
Culture Medium
RPMI 1640 with 10% fetal calf serum
Hybridoma
X63-Ag 8.6.5.3 myeloma cells with spleen cells from Balb/c mice.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Other Notes
Small volumes of anti-PLAUR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PLAUR antibody
Urokinase plasminogen activator receptor (uPAR), also known as CD87, is a glycolipid anchored cell surface protein consisting of three homologous domains. It binds uPA with high affinity and enhancesand localizes uPA catalyzed plasminogen activation, and thereby plays a key role in cancer invasion and in several tissue remodelling processes (1-3). In addition uPAR also binds to vitronectin and may there by have biological functions independent of its role in uPA mediated proteolysis (4,5). Elevated levels of uPAR are associated with poor prognosis in many types of cancer (2,3,6,7).
Applications Tested/Suitable for anti-PLAUR antibody
ELISA (EL/EIA), Immunohistochemistry (IHC)
Application Notes for anti-PLAUR antibody
Suitable for use in ELISA and Immunohistochemistry.
Dilution: ELISA: 1:1000. Use as a detection antibody.
NCBI/Uniprot data below describe general gene information for PLAUR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,978 Da[Similar Products]
NCBI Official Full Name
urokinase plasminogen activator receptor
NCBI Official Synonym Full Names
plasminogen activator, urokinase receptor
NCBI Official Symbol
PLAUR  [Similar Products]
NCBI Official Synonym Symbols
CD87; UPAR; URKR; U-PAR
  [Similar Products]
NCBI Protein Information
urokinase plasminogen activator surface receptor; monocyte activation antigen Mo3; u-plasminogen activator receptor form 2
UniProt Protein Name
Urokinase plasminogen activator surface receptor
UniProt Synonym Protein Names
Monocyte activation antigen Mo3
UniProt Gene Name
PLAUR  [Similar Products]
UniProt Synonym Gene Names
MO3; UPAR  [Similar Products]
UniProt Entry Name
UPAR_HUMAN
NCBI Summary for PLAUR
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq]
UniProt Comments for PLAUR
uPAR: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Expressed in neurons of the rolandic area of the brain. Expressed in the brain. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Motility/polarity/chemotaxis; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 19q13

Cellular Component: endoplasmic reticulum membrane; focal adhesion; extrinsic to membrane; integral to plasma membrane; endoplasmic reticulum lumen; integral to membrane; plasma membrane

Molecular Function: protein domain specific binding; protein binding; enzyme binding; U-plasminogen activator receptor activity; receptor activity; receptor binding

Biological Process: fibrinolysis; cellular protein metabolic process; attachment of GPI anchor to protein; regulation of proteolysis; C-terminal protein lipidation; post-translational protein modification; cell motility; signal transduction; blood coagulation; chemotaxis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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